TTF-1、CD56、P40免疫组化标志物及其他临床特征与小细胞肺癌预后相关性研究

发布时间：2018-06-28 15:20

  本文选题：肺肿瘤 + 预后　； 参考：《中国肺癌杂志》2017年08期

【摘要】：背景与目的本研究旨在分析甲状腺转录因子-1(thyroid transcription factor-1,TTF-1)、神经细胞粘附分子CD56和P40蛋白在小细胞肺癌患者中的阳性表达情况,探讨上述免疫表型标志物及其他临床特征与小细胞肺癌预后的相关性。方法用免疫组织化学方法检测198例初次诊治的小细胞肺癌患者石蜡包埋活检组织标本中TTF-1、CD56、P40的阳性表达情况,观察随访患者临床特征及治疗、生存情况,通过Cox风险比例模型分析上述标志物、临床病理特征与预后的相关性。结果 198例小细胞肺癌患者TTF-1、CD56、P40的阳性率分别为73.2%(145/198)、88.4%(175/198)、7.1%(14/198)。TTF-1是否阳性为小细胞肺癌患者独立预后因素OR=0.665,95%CI:0.472-0.937。其他与预后的相关因素包括:与不吸烟者相比,吸烟指数≤400组OR=1.72,95%CI:1.061-2.789;美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)得分为2分与0分者相比的OR=3.551,95%CI:2.133-5.914;广泛期与局限期患者相比OR=2.487,95%CI:1.793-3.451;合并上腔静脉压迫综合征(superior vena cava syndrome,SVCS)者OR=2.394,95%CI:1.49-3.846。结论小细胞肺癌中的预后与TTF-1表达及吸烟、ECOG得分、肿瘤分期、合并SVCS等多个因素相关,TTF-1、CD56、P40表达在小细胞肺癌的诊断和鉴别诊断中有辅助作用。
[Abstract]:Background & AIM this study was designed to analyze the positive expression of thyroid transcription factor 1 (thyroid transcription factor-1 TTF-1, neural cell adhesion molecule CD56 and P40 protein in patients with small cell lung cancer. To investigate the correlation between the immunophenotypic markers and other clinical features and the prognosis of small cell lung cancer. Methods Immunohistochemical method was used to detect the positive expression of TTF-1 CD56 P40 in paraffin-embedded biopsy specimens of 198 patients with primary small cell lung cancer. The clinical features, treatment and survival of the patients were observed. Cox risk ratio model was used to analyze the correlation between the clinicopathological features and prognosis. Results in 198 patients with small cell lung cancer, the positive rate of TTF-1 CD56 / P40 was 73.2% (14.5 / 198) and 88.4% (175 / 198) respectively. Whether TTF-1 was positive or not was the independent prognostic factor of small cell lung cancer patients: CIW 0.66595and CIW 0.472-0.937. Other prognostic factors include: compared with non-smokers, The smoking index 鈮，

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