血清血脂水平及体重指数与乳腺癌相关性的研究

发布时间：2018-06-29 08:14

本文选题：血脂 + 体重指数　；参考：《南京医科大学学报(自然科学版)》2017年12期

【摘要】：目的 :探讨血清血脂水平及体重指数(BMI)与乳腺癌不同病理特征的相关性。方法 :收集352例乳腺癌患者的临床资料,回顾性分析BMI及血清甘油三酯、总胆固醇、高密度脂蛋白胆固醇水平和乳腺癌肿块大小、淋巴结有无转移、激素受体情况的相关性。结果:BMI与乳腺癌肿块大小、淋巴结有无转移、激素受体情况、绝经与否均无明显相关性;但将患者按绝经状态及激素受体分层后,发现绝经前激素受体阳性患者高BMI者淋巴结转移率高。血清甘油三酯、总胆固醇、高密度脂蛋白胆固醇水平在不同病理特征的乳腺癌患者中均无明显统计差异。按绝经状态和激素受体分层后,发现绝经后激素受体(HR)-患者高血清胆固醇组大肿块的比率减少。结论:BMI与绝经前激素受体阳性患者淋巴结转移呈正相关。血清胆固醇水平与绝经后激素受体阴性患者肿块大小呈负相关。血脂水平及BMI与乳腺癌的关系值得进一步研究。
[Abstract]:Objective: to investigate the relationship between serum lipid level, body mass index (BMI) and different pathological features of breast cancer. Methods: the clinical data of 352 patients with breast cancer were collected and the correlation between BMI, serum triglyceride, total cholesterol, high density lipoprotein cholesterol and tumor size, lymph node metastasis and hormone receptor were analyzed retrospectively. Results there was no significant correlation between BMI and breast cancer tumor size, lymph node metastasis, hormone receptor status, menopausal status or not, but the patients were stratified according to menopausal status and hormone receptor. It was found that premenopausal hormone receptor positive patients with high BMI had high lymph node metastasis rate. Serum triglycerides, total cholesterol and high density lipoprotein cholesterol levels were not significantly different in breast cancer patients with different pathological features. After stratification according to menopausal status and hormone receptor, postmenopausal hormone receptor (HR)-the proportion of large masses in patients with high serum cholesterol was decreased. Conclusion there is a positive correlation between weight BMI and lymph node metastasis in premenopausal hormone receptor positive patients. Serum cholesterol level was negatively correlated with tumor size in postmenopausal hormone receptor negative patients. The relationship between serum lipids and BMI and breast cancer deserves further study.
【作者单位】：南京医科大学附属逸夫医院普外科;江苏大学附属医院甲乳外科;
【分类号】：R737.9

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