溃疡性结肠炎及结直肠癌患者血清MUC1的表达水平及临床意义

发布时间：2018-06-29 23:15

本文选题：炎症性肠病 + 溃疡性结肠炎　；参考：《重庆医科大学》2017年硕士论文

【摘要】：目的:探讨血清黏蛋白1(serum mucin 1,s MUC1)在溃疡性结肠炎、结直肠癌患者以及健康人群血清中的表达水平,分析组间差异,了解其临床意义。方法:收集重庆医科大学附属第二医院2015年9月至2016年年10月确诊溃疡性结肠炎31例,结直肠癌31例为实验组,其中结直肠癌组分为有转移组与无转移组(包括淋巴结及其他脏器转移),从体检中心选择31例健康体检者作为对照组;收集临床病例资料及患者血清,采用ELISA方法检测各组病例血清MUC1水平,分析各组间差异。结果:MUC1在溃疡性结肠炎(8.64±6.09 U/ml,P=0.047)及结直肠癌(9.98±7.75 U/ml,P=0.014)患者血清中的表达明显高于对照组(6.06±3.49 U/ml)。在结直肠癌组中,有转移组(13.80±9.69U/ml)明显高于无转移组(6.82±3.58U/ml),差异具有统计学意义(P=0.010)。而溃疡性结肠炎和结直肠癌组间差异无统计学意义(P=0.453)。结论:MUC1在溃疡性结肠炎及结直肠癌患者血清中表达增高,提示其可能与炎症及肿瘤的发生发展相关,检测其表达水平,对患者炎症程度、肿瘤的发生风险以及肿瘤转移有一定预判价值。
[Abstract]:Objective: to investigate the expression of serum mucin 1 (serum mucin 1s MUC1 in patients with ulcerative colitis, colorectal cancer and healthy people. Methods: from September 2015 to October 2016, 31 patients with ulcerative colitis and 31 patients with colorectal cancer were collected from the second affiliated Hospital of Chongqing Medical University. The colorectal cancer group was divided into two groups: metastasis group and non-metastasis group (including lymph nodes and other organ metastasis). 31 healthy persons were selected as control group from the physical examination center, and the clinical data and serum of the patients were collected. The serum MUC1 level was detected by Elisa and the difference between the groups was analyzed. Results the expression of MUC1 in serum of patients with ulcerative colitis (8.64 卤6.09 U / ml) and colorectal cancer (9.98 卤7.75 U / ml) was significantly higher than that of control group (6.06 卤3.49 U / ml). In the colorectal cancer group, the metastatic group (13.80 卤9.69 U / ml) was significantly higher than the non-metastatic group (6.82 卤3.58 U / ml), the difference was statistically significant (P0. 010). There was no significant difference between ulcerative colitis and colorectal cancer (P = 0.453). Conclusion the increased expression of MUC1 in serum of patients with ulcerative colitis and colorectal cancer suggests that it may be related to the occurrence and development of inflammation and tumor. The risk of tumor and tumor metastasis have certain value.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.34

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