Survivin和Aurora-b在喉癌组织中的表达及其临床意义

发布时间：2018-06-30 04:51

本文选题：喉鳞状细胞癌 + Survivin　；参考：《临床耳鼻咽喉头颈外科杂志》2017年10期

【摘要】：目的:探讨Survivin和Aurora-b在喉癌组织中表达的意义及与其临床病理特征间的联系。探讨Survivin和Aurora-b的表达水平是否具有喉癌生物学标志物的研究价值,以及能否作为喉癌术后预测总生存率的预后指标。方法:收集经病理科确诊的喉癌组织标本86例,同时选取癌旁组织86例和正常组织22例作为对照。采用免疫组织化学法检测Survivin和Aurora-b在喉癌和癌旁及正常组织中的表达情况。结果:Survivin和Aurora-b在喉癌组织中的阳性表达率明显高于癌旁及正常组织,其差异有统计学意义(P0.01)。Survivin蛋白的表达与淋巴结转移、复发情况等临床病理特征有相关性(P0.05),而与年龄、性别、临床分期及分化情况等病理特征无相关性。Aurora-b的表达与临床分期、复发情况等临床病理特征有相关性(P0.05),但与年龄、性别、分化情况及淋巴结转移等病理特征无相关性。生存曲线显示阴性组生存期都比阳性组高,提示Survivin和Aurora-b在喉癌中表达水平具有提示预后的意义,且均为负性预后因子。COX回归分析结果显示,喉癌患者术后Aurora-b表达和复发情况为影响预后的独立危险因素(P0.05);而Survivin表达和淋巴结转移情况则不是影响预后的独立危险因素。结论:本研究表明Survivin和Aurora-b以及两者的协同作用可能在喉癌的发生、发展、转移和预后等方面扮演重要角色,其表达水平与肿瘤的恶性程度和侵袭性正相关,可能是预后不良的提示指征,在诊疗过程中具有预测预后的潜在研究价值。
[Abstract]:Objective: to investigate the expression of survivin and Aurora-b in laryngeal carcinoma and its relationship with clinicopathological features. To explore whether the expression of survivin and Aurora-b is valuable in the study of biological markers of laryngeal carcinoma and whether it can be used as a prognostic index to predict the overall survival rate after laryngeal cancer operation. Methods: 86 cases of laryngeal carcinoma were collected, 86 cases of paracancerous tissue and 22 cases of normal tissue were selected as control group. The expression of survivin and Aurora-b in laryngeal carcinoma and adjacent and normal tissues was detected by immunohistochemical method. Results the positive expression rate of survivin and Aurora-b in laryngeal carcinoma tissues was significantly higher than that in adjacent and normal tissues. The difference was statistically significant (P0.01) .survivin protein expression was correlated with clinicopathological features such as lymph node metastasis and recurrence (P0.05), but it was associated with age and sex. There was no correlation between the expression of Aurora-b and clinical stage and recurrence (P0.05), but there was no correlation with age, sex, differentiation and lymph node metastasis. Survival curve showed that the survival time of the negative group was longer than that of the positive group, suggesting that the expression of survivin and Aurora-b in laryngeal carcinoma had prognostic significance, and both of them were negative prognostic factors. Cox regression analysis showed that survivin and Aurora-b were negative prognostic factors. The expression and recurrence of Aurora-b were independent prognostic factors in laryngeal cancer patients (P0.05), while survivin expression and lymph node metastasis were not independent prognostic factors. Conclusion: this study suggests that survivin, Aurora-b and their synergistic effects may play an important role in the occurrence, development, metastasis and prognosis of laryngeal carcinoma. The expression level of survivin and Aurora-b is positively correlated with the malignancy and invasiveness of the tumor. It may be an indication of poor prognosis and has potential research value in predicting prognosis in the course of diagnosis and treatment.
【作者单位】：桂林医学院;桂林医学院附属医院耳鼻咽喉头颈外科;桂林医学院附属医院耳鼻咽喉头颈外科研究所;桂林医学院附属医院病理科;
【基金】：基金项目:人口健康安全技术开发与应用研究(No:2016012706-4)
【分类号】：R739.6

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