喉神经内分泌癌的临床研究

发布时间：2018-06-30 20:21

本文选题：喉肿瘤 + 神经内分泌癌　；参考：《临床耳鼻咽喉头颈外科杂志》2017年23期

【摘要】：目的:探讨喉神经内分泌癌的临床表现、诊断、治疗及预后。方法:回顾性分析病理确诊为喉神经内分泌癌的26例患者的临床资料,典型类癌1例,不典型类癌15例,神经内分泌型小细胞癌9例,混合性神经内分泌型小细胞癌1例。12例行全喉切除术、2例行喉环状软骨上部分切除环舌骨固定术、4例行喉水平部分切除术、5例行喉垂直部分切除术、1例行经口CO_2激光喉显微手术、2例单纯接受放/化疗。结果:3年、5年总体生存率分别为76.9%和69.2%。结论:喉神经内分泌癌临床罕见,临床表现无特异性,其中不典型类癌最常见,病变以声门上区多见,各病理亚型的生物学行为、治疗及预后差别较大,确诊需全面的免疫组织化学检测。
[Abstract]:Objective: to investigate the clinical manifestations, diagnosis, treatment and prognosis of laryngeal neuroendocrine carcinoma. Methods: the clinical data of 26 patients with pathologically diagnosed laryngeal neuroendocrine carcinoma were retrospectively analyzed, including 1 typical carcinoid, 15 atypical carcinoid and 9 neuroendocrine small cell carcinoma. Mixed neuroendocrine small cell carcinoma: total laryngectomy 1 case. 12 cases total laryngectomy 2 cases laryngeal annular cartilage partial excision 4 cases horizontal partial laryngectomy 5 cases perpendicular laryngectomy 1 case oral COS2 Two cases of laser laryngeal microsurgery were treated with radiotherapy / chemotherapy alone. Results: the 3-year and 5-year overall survival rates were 76. 9% and 69. 2%, respectively. Conclusion: laryngeal neuroendocrine carcinoma is rare in clinic and has no specific clinical manifestation. Atypical carcinoid is the most common, and the lesions are more common in the supraglottic region. The biological behavior, treatment and prognosis of various pathological subtypes vary greatly. A complete immunohistochemical test is required for diagnosis.
【作者单位】：复旦大学附属眼耳鼻喉科医院耳鼻咽喉科;复旦大学附属眼耳鼻喉科医院病理科;
【基金】：上海市自然科学基金项目(No:17ZR1404700) 上海市浦东新区卫生局卫生(计生)科技项目(No:PW2016D-11) 上海市级医院新兴前沿技术联合攻关项目(No:SHDC12015114)
【分类号】：R739.65

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