基于Oncomine数据库荟萃分析KIF23在非小细胞肺癌中的表达和意义

发布时间：2018-07-02 19:27

本文选题：肺肿瘤 + 驱动蛋白超家族　；参考：《中国肺癌杂志》2017年12期

【摘要】：背景与目的非小细胞肺癌(non-small cell lung cancer,NSCLC)是全球引起死亡的最重要原因之一。大多数患者发现时处于中晚期,预后较差。本研究拟探讨驱动蛋白超家族23(kinesin family member 23,KIF23)在NSCLC中的表达及意义。方法收集Oncomine数据库中关于KIF23的信息,并对目前数据库中资料进行二次分析,对其在NSCLC中的作用进行荟萃分析。利用Kaplan-Meier Plotter进行患者生存周期分析。结果 Oncomine数据库中共收集了447项不同类型的研究结果,其中关于KIF23表达有统计学差异的研究结果有67个,KIF23表达增高的研究有64项、表达降低的研究有3项。共有16项研究涉及KIF23在NSCLC癌组织和正常组织中的表达,共包括1,189个样本,与对照组相比,KIF23在NSCLC细胞癌中高表达(P0.05)。不仅如此,KIF23表达量与NSCLC总体生存率存在相关性,高表达KIF23的患者总体生存率较差,低表达KIF23的患者预后较好(P0.05)。进一步亚组分析发现,KIF23表达水平对肺腺癌患者预后有显著影响,而在鳞癌患者中,其表达水平对预后无显著影响。结论我们通过对Oncomine基因芯片数据库中肿瘤相关基因信息的深入挖掘,提出KIF23在NSLCL组织中高表达,且与NSCLC预后有关,可能为肿瘤药物的开发提供重要理论依据。
[Abstract]:Background and objective Non-small cell lung cancer (NSCLC) is one of the most important causes of death in the world. Most of the patients were found in the late stage and poor prognosis. The purpose of this study was to investigate the expression and significance of 23 (kinesin family member 23 KIF23 in NSCLC. Methods the information about KIF23 in Oncomine database was collected, and the data in current database was analyzed twice, and the role of KIF23 in NSCLC was analyzed by meta-analysis. Kaplan-Meier Plotter was used to analyze the life cycle of patients. Results A total of 447 different types of research results were collected in Oncomine database. Among them, there were 67 cases of high expression of KIF23 and 3 cases of decreased expression of KIF23. A total of 16 studies involved KIF23 expression in NSCLC tissues and normal tissues, including 1189 samples, compared with the control group in NSCLC cell carcinoma overexpression of KIF23 (P0.05). Moreover, the expression of KIF23 was correlated with the overall survival rate of NSCLC. The overall survival rate of patients with high expression of KIF23 was poor, and the prognosis of patients with low expression of KIF23 was better than that of patients with low expression of KIF23 (P0.05). Further subgroup analysis showed that the expression level of KIF23 had a significant effect on the prognosis of lung adenocarcinoma, but had no significant effect on the prognosis of squamous cell carcinoma. Conclusion by digging oncomine gene chip database, we suggest that KIF23 is highly expressed in NSLCL and is related to the prognosis of NSCLC, which may provide an important theoretical basis for the development of tumor drugs.
【作者单位】：南京医科大学金陵临床医学院呼吸内科;南京医科大学附属南京医院(南京市第一医院)呼吸内科;
【基金】：国家自然科学基金项目(No.81270079,No.81570025)资助~~
【分类号】：R734.2

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