益气复脉对中晚期肺癌患者免疫功能和生存质量的影响

发布时间：2018-07-02 22:40

本文选题：注射用益气复脉 + 肺癌　；参考：《中国现代医学杂志》2017年06期

【摘要】：目的探讨注射用益气复脉(冻干)对中、晚期肺癌患者免疫功能和生存质量的影响。方法选取2013年9月-2014年8月在该院经组织病理学或细胞学确诊为中、晚期肺癌并化疗的患者63例为对照组;选择2015年1月-2015年12月该院同类患者67例为观察组。两组患者给予相同的化疗方案,辅助健康指导、营养支持、心理及康复锻炼指导,并给予止痛、止呕等治疗。观察组在对照组的基础上加用注射用益气复脉。6个疗程后比较两组的免疫功能血液学指标、生存质量、卡氏评分、疗效及不良反应。结果观察组可降低C-反应蛋白和白细胞的数量,增加NKT细胞活性,增加T细胞亚群中CD3~+、CD4~+及CD4/CD8~+的比例,增强机体的免疫功能。治疗前两组患者的生存质量评分差异无统计学意义,治疗后两组患者的生存质量均提高。观察组患者在认知功能和经济困难方面与对照组患者改善程度一致,在其他维度方面优于对照组。治疗后观察组患者卡氏评分与对照组比较,差异有统计学意义(P0.05)。观察组患者显效率为95.52%,对照组为60.32%,差异有统计学意义(P0.05)。观察组白细胞计数下降、血小板计数下降、血红蛋白下降、肝功能异常、肾功能异常比例比较,差异有统计学意义(P0.05)。结论注射用益气复脉不仅可提高机体的免疫功能,而且可减少不良反应的发生,提高患者生存质量。
[Abstract]:Objective to investigate the effect of Yiqi Fumai (lyophilized) for injection on immune function and quality of life in patients with middle and advanced lung cancer. Methods Sixty-three patients with advanced lung cancer combined with chemotherapy were selected as control group from September 2013 to August 2014, and 67 patients from January 2015 to December 2015 were selected as observation group. The two groups were given the same chemotherapy regimen, supplementary health guidance, nutritional support, psychological and rehabilitation exercise guidance, pain relief, nausea and other treatment. After 6 courses of treatment, the immune function hematological indexes, quality of life, Karschoff score, curative effect and adverse reactions were compared between the two groups. Results the observation group could decrease the number of C-reactive protein and leukocytes, increase the activity of NKT cells, increase the proportion of CD3 ~ + CD4 ~ and CD4 ~-/ -CD8 ~ in T cell subsets, and enhance the immune function of the body. There was no significant difference in quality of life score between the two groups before treatment. The improvement of cognitive function and economic difficulty in the observation group was consistent with that in the control group, and was superior to the control group in other dimensions. After treatment, the observation group patients compared with the control group, the difference was statistically significant (P0.05). The effective rate of observation group was 95.52 and that of control group was 60.32, the difference was statistically significant (P0.05). The proportion of leukocyte count, platelet count, hemoglobin, liver function abnormality and renal function abnormality in the observation group were significantly lower than those in the control group (P0.05). Conclusion invigorating qi and tonifying veins for injection can not only improve the immune function, but also reduce the occurrence of adverse reactions and improve the quality of life of the patients.
【作者单位】：青海大学附属医院中西医结合科;
【基金】：青海大学附属医院中青年科研基金(No:ASRF-2014-03)
【分类号】：R734.2

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