Bax、nm23蛋白在甲状腺微小乳头状癌的表达及意义

发布时间：2018-07-05 08:25

本文选题：甲状腺微小乳头状癌 + Bax　；参考：《实用医学杂志》2017年19期

【摘要】：目的探讨Bax、nm23蛋白在甲状腺微小乳头状癌的表达及临床意义。方法应用免疫组化(Maxvision~(TM)/HRP免疫组化染色法)检测70例甲状腺微小乳头状癌、70例甲状腺腺瘤、62例癌旁甲状腺正常组织中Bax、nm23蛋白的表达。结果甲状腺微小乳头状癌、甲状腺腺瘤、癌旁甲状腺正常组织中Bax蛋白阳性率依次为65.71%、52.86%、0;Bax蛋白在甲状腺微小乳头状癌、甲状腺腺瘤中表达差异无统计学意义(P0.05);其在甲状腺微小乳头状癌、癌旁甲状腺正常组织中表达差异有统计学意义(P0.01);其在甲状腺腺瘤、癌旁甲状腺正常组织中表达差异有统计学意义(P0.01)。其与年龄、性别无相关性(P0.05)。其与局部淋巴结转移呈负相关(P0.01)。甲状腺微小乳头状癌、甲状腺腺瘤、癌旁甲状腺正常组织中nm23蛋白阳性率依次为72.86%、34.29%、24.19%;nm23蛋白在甲状腺微小乳头状癌、甲状腺腺瘤中表达差异有统计学意义(P0.01);其在甲状腺微小乳头状癌、癌旁甲状腺正常组织中表达差异有统计学意义(P0.01);其在甲状腺腺瘤、癌旁甲状腺正常组织中表达差异无统计学意义(P0.05)。其与年龄、性别无相关性(P0.05)。其与局部淋巴结转移呈负相关(P=0.005),Bax和nm23蛋白表达在甲状腺微小乳头状癌中呈正相关性(P0.01)。结论 Bax、nm23蛋白表达与甲状腺微小乳头状癌的发生、发展及局部淋巴结转移相关,两者联合检测对甲状腺微小乳头状癌辅助诊断及局部淋巴结转移有指导意义。
[Abstract]:Objective to investigate the expression and clinical significance of Baxnm23 protein in thyroid micropapillary carcinoma. Methods the expression of Baxnm23 protein in 70 cases of thyroid micropapillary carcinoma and 70 cases of thyroid adenoma adjacent to normal thyroid tissues was detected by immunohistochemistry (Maxvision- ~ (TM) / HRP immunohistochemical staining). Results the positive rate of Bax protein in thyroid micropapillary carcinoma, thyroid adenoma and adjacent normal thyroid tissue was 65.71 and 52.860.The positive rate of Bax protein in thyroid micropapillary carcinoma was 65.71 and 52.860.The positive rate of Bax protein in thyroid micropapillary carcinoma was 52.86%. There was no significant difference in the expression of thyroid adenoma (P0.05); there was significant difference in the expression of thyroid adenoma in thyroid micropapillary carcinoma and adjacent normal thyroid tissue (P0.01). There was significant difference in the expression of normal thyroid tissues (P0.01). There was no correlation between age and sex (P0.05). It was negatively correlated with local lymph node metastasis (P0.01). The positive rates of nm23 protein in thyroid micropapillary carcinoma, thyroid adenoma, and adjacent normal thyroid tissue were 72.86 and 34.29, respectively, and 24.19nm23 protein was detected in thyroid micropapillary carcinoma. There were significant differences in the expression of thyroid adenoma (P0.01), in thyroid micropapillary carcinoma (P0.01) and in the adjacent normal thyroid tissue (P0.01). There was no significant difference in the expression of paracancerous thyroid tissues (P0.05). There was no correlation between age and sex (P0.05). The expression of Bax and nm23 protein was negatively correlated with local lymph node metastasis (P0. 005) in thyroid micropapillary carcinoma (P0. 01). Conclusion the expression of Baxannm23 protein is related to the occurrence, development and local lymph node metastasis of thyroid micropapillary carcinoma. The combined detection of Baxnm23 protein and Baxnm23 protein may be helpful in the diagnosis of thyroid micropapillary carcinoma and local lymph node metastasis.
【作者单位】：湖北医药学院附属东风医院肝胆胰甲状腺外科;湖北医药学院附属东风医院实验中心;湖北医药学院附属东风医院病理科;
【基金】：湖北省科学技术研究与开发项目(编号:2014CFB310) 湖北省教育厅青年人才项目(编号:Q20162112)
【分类号】：R736.1

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