室内空气污染、HIF-1α基因单核苷酸多态性与福建汉族肺癌易感性的关系

发布时间：2018-07-07 22:37

本文选题：HIF-α + rs　；参考：《中国肺癌杂志》2017年03期

【摘要】：背景与目的低氧诱导因子-1α(hypoxia inducible factor 1α,HIF-1α)与肺癌的恶化与转移有关,但HIF-1α的单核苷酸多态性(single nucleotide polymorphisms,SNPs)与肺癌易感性的研究仍较少。本研究旨在探讨室内空气污染、rs2057482多态性与福建汉族肺癌易感性的关系。方法采用以医院为基础的病例对照设计,选择2006年1月-2012年12月在福建医科大学附属第一医院、协和医院和南京军区福州总医院的胸外科及呼吸内科病理确诊的汉族新发原发性肺癌患者1,096例,选取无肿瘤病史、同期前往医院其他科室探视的患者汉族亲友和社区汉族人群1,110例,进行问卷调查。应用MALDI-TOF-MS技术对所有研究对象HIF-1α基因rs2057482位点多态性进行基因分型。结果携带有HIF-1αrs2057482位点T基因型的人群更容易罹患小细胞癌[TT vs CC的比值比(odds ratio,OR)值为1.725,95%CI:1.047-2.842]。调整一般情况和肺癌有关影响因素后,在共显性遗传模型中,暴露于被动吸烟的rs2057482 TT携带者肺癌患病风险是CC携带者的2.195倍(95%CI:1.038-4.643)。在显性遗传模型中,有肿瘤家族史的rs2057482 T基因携带者肺癌患病风险是C基因携带者的1.911倍(95%CI:1.121-3.258)。在隐性遗传模型中,肺部疾病史的rs2057482 TT携带者的肺癌患病风险是TC+CC携带者的0.159倍(95%CI:0.028-0.920)。在加性遗传模型中,有肿瘤家族史的rs2057482 TC+TT携带者的肺癌患病风险是CC携带者的1.542倍(95%CI:1.107-2.340)。结论 HIF-1αrs2057482位点可能与肺癌易感性存在一定关联。
[Abstract]:Background & objective hypoxic inducible factor 1 伪 (hypoxia inducible factor 1 伪 (HIF-1 伪) is associated with the deterioration and metastasis of lung cancer, but the single nucleotide polymorphisms (single nucleotide polymorphismsns of HIF-1 伪 and the susceptibility to lung cancer are still less studied. The aim of this study was to investigate the relationship between the polymorphism of indoor air pollution rs2057482 and the susceptibility to lung cancer in Fujian Han nationality. Methods A case-control design based on hospital was used to select the first affiliated Hospital of Fujian Medical University from January 2006 to December 2012. 1096 newly diagnosed Han patients with primary lung cancer were selected from the Department of Thoracic surgery and the Department of Respiratory Medicine of Xianghe Hospital and Fuzhou General Hospital of Nanjing military region. At the same time, 1110 cases of relatives and friends of Han nationality and Han nationality in community were investigated by questionnaire. Rs2057482 polymorphism of HIF-1 伪 gene was genotyped by MALDI-TOF-MS. Results people with HIF-1 伪 rs2057482 locus T genotype were more likely to develop small cell carcinoma [odds ratioor (TT vs CC) = 1.725 / 95 CI: 1.047-2.842]. After adjusting for general conditions and factors related to lung cancer, the risk of lung cancer in rs2057482 TT carriers exposed to passive smoking was 2.195 times higher than that of CC carriers (95 CI: 1.038-4.643) in the codominant genetic model. In the dominant genetic model, rs2057482 T carriers with a family history of cancer were 1.911 times more likely to develop lung cancer than those with C gene (95 CI: 1.121-3.258). In the recessive genetic model, the risk of lung cancer in rs2057482 TT carriers with history of lung disease was 0.159 times higher than that in TC CC carriers (95 CI: 0.028-0.920). In the additive genetic model, the risk of lung cancer in rs2057482 TTC TT carriers with a family history of cancer was 1.542 times higher than that in CC carriers (95 CI: 1.107-2.340). Conclusion HIF-1 伪 rs2057482 may be associated with lung cancer susceptibility.
【作者单位】：福建医科大学公共卫生学院流行病与卫生统计学系;福建医科大学附属第一医院胸外科;
【基金】：国家自然科学基金青年项目(No.81402738) 福建省自然科学基金面上项目(No.2016J01355) 福建省卫生计生委青年科研项目(No.2014-1-37)资助~~
【分类号】：R734.2

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