颅底畸胎癌肉瘤2例临床病理分析

发布时间：2018-07-09 11:24

  本文选题：颅底肿瘤 + 畸胎癌肉瘤　； 参考：《临床与实验病理学杂志》2017年11期

【摘要】：目的探讨发生于颅底的畸胎癌肉瘤临床病理特征、诊断与鉴别诊断。方法采用形态学观察及免疫组化En Vision两步法对2例发生于颅底的畸胎癌肉瘤进行分析,并复习相关文献。结果例1男性,以颅底占位就诊;例2女性,以鞍区占位就诊;例1患者2年后复发1次,同时在复发当年并发右肾血管平滑肌脂肪瘤,例2随访无复发。肿瘤组织成分复杂,形态多样,可见未成熟的鳞状细胞巢及腺样结构和畸胎瘤成分以及肉瘤成分,间质中可见未分化/原始间叶细胞,免疫组化标记显示不同成分表达不同标志物;其与鼻腔鼻窦畸胎癌肉瘤形态与免疫表型相似。结论畸胎癌肉瘤属于罕见的恶性肿瘤,好发于鼻腔鼻窦,发生于颅底者罕见,临床易误诊,诊断及鉴别诊断主要依靠病理形态观察和免疫表型分析。
[Abstract]:Objective to investigate the clinicopathological features, diagnosis and differential diagnosis of teratosarcoma in the skull base. Methods two cases of teratosarcoma in the skull base were analyzed by morphological observation and immunohistochemical en Vision method, and the related literatures were reviewed. Results case 1, male, with skull base occupying, case 2, female, with Sellar area, case 1 recurred once 2 years later, at the same time, right renal angiomyolipoma was complicated with right renal angiomyolipoma in the year of recurrence. No recurrence was found in case 2. The tumor tissue components were complex and varied, with immature squamous cell nests and adenoid structures, teratoma components and sarcoma components, and undifferentiated / primitive mesenchymal cells in the stroma. The expression of different markers was similar to the morphology and immunophenotype of teratosarcoma of nasal cavity and paranasal sinus. Conclusion teratosarcoma is a rare malignant tumor, which usually occurs in the nasal cavity and paranasal sinus, and is rare in the skull base. The diagnosis and differential diagnosis of teratosarcoma are mainly based on pathological observation and immunophenotypic analysis.
【作者单位】： 江西省赣州市人民医院病理科;
【基金】：江西省卫生计划委科技计划(20157173) 赣州市科技计划(GZ2015ZSF111)
【分类号】：R739.4
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本文编号：2109197