自拟理气和胃汤联合XELOX方案对胃癌术后患者的临床疗效观察

发布时间：2018-07-10 00:21

本文选题：自拟理气和胃汤 + 胃癌术后　；参考：《黑龙江中医药大学》2017年硕士论文

【摘要】：目的:探讨自拟理气和胃汤联合XELOX方案对胃癌术后肝胃不和型患者的临床疗效。方法:将符合纳入标准的90例患者随机分为治疗组与对照组,两组各45例患者。对照组给予XELOX方案化疗(卡培他滨1000mg/m2,口服Bid,d1-d14;奥沙利铂130mg/m2,iv d1),治疗组在对照组治疗的基础上加服自拟理气和胃汤(300ml,分早晚两次口服)。两组均以21天为一个周期,治疗两个周期。观察患者中医证候评分、肿瘤标志物、KPS评分、毒副反应等变化。结果:1.治疗后,两组患者的中医证候评分较治疗前均下降,差异有统计学意义(p0.05)。2.治疗后,两组患者的肿瘤标志物(CEA、CA19-9、CA72-4)与治疗前相比均降低,差异有统计学意义(p0.05)。3.治疗后,两组患者的KPS评分与治疗前相比均提高,差异有统计学意义(p0.05)。治疗组与对照组相比,治疗组KPS评分比对照组提高更为显著(p0.05)。4.治疗后,两组患者均有不同程度的毒副反应。治疗组白细胞、血红蛋白减少发生率、消化道反应发生率低于对照组,差异有统计学意义(p0.05):5.治疗组手足综合征、神经毒性、血小板减少发生率虽与对照组相比降低,但差异无统计学意义(p0.05)。结论:1.自拟理气和胃汤联合XELOX方案治疗胃癌术后肝胃不和型患者较单纯XELOX方案相比,可降低患者血清肿瘤标志物水平,提高临床疗效。2.自拟理气和胃汤联合XELOX方案较单纯XELOX方案能够改善患者临床症状,提高其生活质量。3.自拟理气和胃汤可改善XELOX方案所导致的骨髓抑制及减轻消化道反应。
[Abstract]:Objective: to investigate the clinical effect of self-made decoction of regulating qi and stomach combined with XELOX regimen in patients with hepatogastric disharmony after operation of gastric cancer. Methods: 90 patients were randomly divided into treatment group (n = 45) and control group (n = 45). The control group was treated with XELOX regimen (capecitabine 1000mg / m2, Bidd1-d14; oxaliplatin 130mg / m2 iv D1). The treatment group was treated with self-made decoction of regulating qi and stomach (300ml, twice in the morning and evening). Both groups were treated with 21 days for one cycle and two cycles for treatment. The changes of TCM syndrome score, tumor marker KPS score and toxicity were observed. The result is 1: 1. After treatment, the TCM syndrome scores of the two groups decreased compared with those before treatment, the difference was statistically significant (p0.05). 2. After treatment, the tumor markers (CEACA19-9, CA72-4) in both groups were significantly lower than those before treatment (p0.05). After treatment, the KPS scores of the two groups were significantly higher than those before treatment (p0.05). Compared with the control group, the KPS score in the treatment group was significantly higher than that in the control group (p0.05). 4. After treatment, the two groups of patients have varying degrees of toxic side effects. The incidence of leukocyte, hemoglobin reduction and digestive tract reaction in the treatment group was lower than that in the control group (p0.05): 5. The incidence of hand and foot syndrome, neurotoxicity and thrombocytopenia in the treatment group was lower than that in the control group, but the difference was not statistically significant (p0.05). Conclusion 1. Compared with the simple XELOX regimen, the self-made regimen of regulating qi and stomach decoction combined with XELOX can reduce the level of serum tumor markers and improve the clinical efficacy. 2. Compared with XELOX alone, self-made regimen of regulating qi and stomach decoction combined with XELOX can improve the clinical symptoms and improve the quality of life of the patients. Self-made decoction of regulating qi and stomach can improve bone marrow depression and alleviate digestive tract reaction caused by XELOX regimen.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.2

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