胎盘生长因子在多发性骨髓瘤中的表达及临床意义

发布时间：2018-07-10 14:12

本文选题：胎盘生长因子 + 多发性骨髓瘤　；参考：《临床血液学杂志》2015年03期

【摘要】：目的:检测胎盘生长因子(PLGF)在多发性骨髓瘤(MM)中的表达水平,分析其与MM的临床分期、分型及预后的关系,进一步探讨其临床意义。方法:采用酶联免疫吸附法(ELISA)检测33例MM患者(初治16例,进展期6例,稳定期11例)与20例健康对照者骨髓液和外周血中PLGF的表达水平。结果:MM初治组和进展期组骨髓液及外周血的PLGF水平均明显高于对照组(P0.05)。PLGF水平在稳定期组中明显减低,与初治组比较差异有统计学意义(P0.05)。MM患者骨髓液及外周血中PLGF的水平均随着ISS分期增高而升高,但各期之间差异无统计学意义(P0.05),各分型之间也均无统计学意义(均P0.05),骨髓与外周血的PLGF表达具有相关性,且外周血显著高于骨髓。结论:PLGF异常表达与MM的发生、发展及预后有关,因此检测MM患者PLGF的表达水平可能对评估病情和判断预后有重要意义。
[Abstract]:Objective: to investigate the expression of placental growth factor (PLGF) in multiple myeloma (MM) and its relationship with clinical staging, classification and prognosis. Methods: enzyme linked immunosorbent assay (Elisa) was used to detect the expression of PLGF in bone marrow fluid and peripheral blood of 33 cases of MM (16 cases of primary treatment, 6 cases of advanced stage, 11 cases of stable phase) and 20 healthy controls. Results the levels of PLGF in bone marrow fluid and peripheral blood of the first and advanced groups were significantly higher than those in the control group (P0.05). The level of PLGF in the stable group was significantly lower than that in the control group. The level of PLGF in bone marrow fluid and peripheral blood of MM patients increased with the increase of ISS stage. However, there was no significant difference between each stage (P0.05), and there was no statistical significance among the types (P0.05). The expression of PLGF in bone marrow and peripheral blood was significantly higher than that in bone marrow. Conclusion the abnormal expression of 1% PLGF is related to the occurrence, development and prognosis of MM. Therefore, the detection of the expression level of PLGF in MM patients may be of great significance in evaluating the condition of the disease and judging the prognosis.
【作者单位】：青岛大学附属医院液内科;
【分类号】：R733.3

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