中医治疗放射性肠炎疗效的Meta分析

发布时间：2018-07-11 21:22

本文选题：中医 + 放射性肠炎　；参考：《辽宁中医药大学》2015年硕士论文

【摘要】：目的:对中医治疗放射性肠炎的RCT文献进行Meta分析,评价中医对放射性肠炎的治疗效果,探讨其临床价值。方法:计算机检索中文数据库包括相关期刊论文、万方数据库、维普中文科技期刊数据库和中国生物医学文献数据库,外文数据库以Pub Med为主;手工检索计算机数据库尚未录入的近期发表的文献;对计算机及手工检索到文献的参考文献进一步检索。采用Stata12.0软件对符合纳入标准的文献进行Meta分析。以中医治疗放射性肠炎的有效率、治疗后放射性肠炎患者症状评分、生活质量评分的改善情况以及肠镜下肠粘膜的变化情况为评价指标。结果:1.本研究纳入15篇文献共1363例患者,均为中文文献,文献质量评价不高。2.Meta分析结果:(1)在中医治疗放射性肠炎的有效率方面,中医治疗组与西药对照组相比差异有统计学意义(P0.05),OR=2.86(95%CI:2.18,3.74)。(2)在改善放射性肠炎患者症状(腹痛、腹泻、粘液脓血便、乏力)评分方面,治疗组优于对照组,差异均有统计学意义(P0.05),合并效应量分别为:SMD(95%CI):0.745(0.541,0.948),SMD(95%CI):0.756(0.552,0.959),SMD(95%CI):0.768(0.443,1.092),SMD(95%CI):0.834(0.586,1.081)。(3)在肠镜下肠粘膜改善方面,治疗组较对照组可提高其有效率,差异有统计学意义(P0.05),OR=3.281(95%CI:1.868,5.761)。(4)在改善Karnofsky行为状态评分(KPS)方面,治疗组优于对照组,差异有统计学意义(P0.05),SMD=1.096(95%CI:0.788,1.403)。结论:1中医疗法可提高放射性肠炎治疗的有效率,对改善患者腹痛、腹泻、粘液脓血便以及乏力等症状有较好疗效,并能促进肠镜下肠粘膜病变结局的良好转化,提高患者的生活质量。2清热利湿法在放射性肠炎的中医治疗中应用频率较高、疗效好,可从湿、热、毒、瘀、虚等方面进行辨证论治。3中医疗法在放射性肠炎治疗方面有一定应用价值,值得临床进一步推广应用,尚需进一步结合循证医学方法探究放射性肠炎最佳的中医治疗方法。
[Abstract]:Objective: to analyze the RCT literature of Chinese medicine for the treatment of radioactive enteritis by Meta, to evaluate the therapeutic effect of traditional Chinese medicine on radiological enteritis, and to discuss its clinical value. The database is based on Pub Med; manually retrieving the recent published literature that has not been recorded by the computer database; further retrieval of the reference documents of the computer and the manual retrieval. The Stata12.0 software is used for the Meta analysis of the documents which conform to the standard. The effective treatment of radiative enteritis with Chinese medicine and the treatment of postoperative radioactive enteritis The symptom score, the improvement of quality of life score and the changes of intestinal mucosa under the enteroscopy were evaluated. Results: 1. the 15 literature included 1363 patients, all of which were Chinese literature, and the quality evaluation of the literature was not high.2.Meta analysis results: (1) in the treatment of radiation enteritis in traditional Chinese medicine, the treatment group of Chinese medicine and Western Medicine The differences were statistically significant (P0.05), OR=2.86 (95%CI:2.18,3.74). (2) in improving the symptoms of patients with radiation enteritis (abdominal pain, diarrhea, mucous pus and stool, fatigue) scores, the treatment group was better than the control group, the difference was statistically significant (P0.05): SMD (95%CI): 0.745 (0.541,0.948), SMD (95%CI): 0.756 (0.552,0.). 959), SMD (95%CI): 0.768 (0.443,1.092), SMD (95%CI): 0.834 (0.586,1.081). (3) the improvement of intestinal mucosa in the enteroscope, the treatment group can improve its efficiency compared with the control group, the difference is statistically significant (P0.05), OR=3.281 (95%CI:1.868,5.761). (4) in the improvement of Karnofsky behavior status score (KPS), the treatment group is better than the control group, the difference is statistically significant Significance (P0.05), SMD=1.096 (95%CI:0.788,1.403). Conclusion: 1 Chinese medicine therapy can improve the efficiency of radiation enteritis treatment, improve the patient's abdominal pain, diarrhea, mucus pus and stool and fatigue and other symptoms, and promote the good transformation of the outcome of intestinal mucosal lesion under the enteroscopy, improve the quality of life of the patients.2 clearing heat and wet method in radiation The traditional Chinese medicine treatment of enteritis has high frequency and good curative effect. It can be applied in the treatment of radioactive enteritis from the aspects of damp, heat, poison, stasis and deficiency. It has certain applied value in the treatment of radioactive enteritis. It is worth further popularization and application. It is still necessary to further combine the methods of evidence-based medicine to explore the best methods of Chinese medicine for radioenteritis.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R730.5

【参考文献】