108例三阴性乳腺癌临床特征分析

发布时间：2018-07-12 14:04

本文选题：乳腺癌 + 三阴性乳腺癌　；参考：《时珍国医国药》2017年01期

【摘要】：目的观察和分析三阴性乳腺癌患者的基本临床特征。方法采用回顾性队列研究,分析总结三阴性乳腺癌患者的临床特征,并与HER-2阳性患者进行比较。结果共108例三阴性和53例HER-2过表达乳腺癌术后患者纳入研究。三阴性乳腺癌患者平均年龄47岁左右,主要术式为改良根治术,主要病理类型为浸润性导管癌,36.1%的患者腋下淋巴结阳性,49.3%的患者Ki67阳性,术后转移8例(7.4%)。与HER-2过表达患者比较,三阴性乳腺癌患者年龄低,更偏向于选择保乳术,Ki67表达水平高。三阴性乳腺癌主要中医临床特征表现为虚实夹杂,虚证为气阴两虚和冲任失调,实证为痰浊、血瘀、毒结等,三阴性和HER-2过表达乳腺癌患者中医临床特征相似。结论三阴性乳腺癌患者临床特征与HER-2过表达乳腺癌患者有所差异,但中医临床表现两者相似,提示在临床实践中,中医药诊治乳腺癌可能更多从宏观处着眼,并不受限于基因靶目标。
[Abstract]:Objective to observe and analyze the basic clinical features of triple negative breast cancer patients. Methods retrospective cohort study was used to analyze and summarize the clinical features of triple negative breast cancer patients and compared with HER-2 positive patients. Results 108 patients with triple negative and 53 patients with HER-2 overexpression were included in the study. The average age of the patients with triple negative breast cancer was about 47 years old. The main operative method was modified radical mastectomy. The main pathological type was invasive ductal carcinoma (36.1%). Ki67 was positive in 49.3% of the patients with invasive ductal carcinoma and 8 patients (7.4%) had postoperative metastasis. Compared with patients with HER-2 overexpression, triple negative breast cancer patients had lower age and higher expression of Ki67. The main clinical features of triple negative breast cancer are deficiency and excess, deficiency of qi and yin and disorder of blood stasis, toxic knot and so on. The clinical characteristics of three negative and HER-2 overexpression breast cancer patients are similar in traditional Chinese medicine. Conclusion the clinical features of triple negative breast cancer patients are different from that of HER-2 overexpression breast cancer patients, but the clinical manifestations of traditional Chinese medicine are similar, which suggests that the diagnosis and treatment of breast cancer with traditional Chinese medicine may be more macroscopic in clinical practice. It is not limited to the target of the gene.
【作者单位】：上海中医药大学附属市中医医院上海市中医医院;上海中医药大学附属龙华医院;
【基金】：第五批全国老中医药专家学术经验继承班课题上海市卫生和计划生育委员会中医药继承专项研究课题(No.2014S25)
【分类号】：R737.9

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