乙醛脱氢酶1在宫颈癌发生发展中作用的研究进展

发布时间：2018-07-12 15:01

本文选题：乙醛脱氢酶 + 肿瘤干细胞　；参考：《吉林大学学报(医学版)》2017年01期

【摘要】：乙醛脱氢酶1(ALDH1)是干细胞生长和分化的必需物质。国内外研究表明:ALDH1参与肿瘤干细胞的自我更新、分化和自我保护,与肿瘤的发生发展有密切关联,可作为肿瘤治疗的特异性靶点。本文作者将从ALDH1作为宫颈癌干细胞标志物及其与宫颈癌复发、转移、预后和放化疗抵抗等方面的研究进展进行综述。
[Abstract]:Aldehyde dehydrogenase 1 (ALDH 1) is an essential substance for stem cell growth and differentiation. Studies at home and abroad show that: ALDH1 is involved in the self-renewal, differentiation and self-protection of tumor stem cells, and is closely related to the occurrence and development of tumor, and can be used as a specific target for tumor therapy. This article reviews ALDH1 as a marker of cervical cancer stem cells and its relationship with cervical cancer recurrence, metastasis, prognosis and chemoradiotherapy resistance.
【作者单位】：吉林大学第一医院妇产科;
【基金】：国家自然科学基金资助课题(31430021)
【分类号】：R737.33

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