上皮间质转化在干细胞诱导分化及肿瘤发生中的作用

发布时间：2018-07-12 19:56

本文选题：干细胞 + 肿瘤　；参考：《中国组织工程研究》2017年17期

【摘要】：背景:上皮间质转化与胚胎发育、干细胞诱导分化、损伤组织修复、肿瘤发生发展密切相关。目的:综述上皮间质转化在干细胞诱导分化和肿瘤发生中的作用。方法:应用计算机检索2001至2016年CNKI数据库和Pub Med数据库中相关文献,检索关键词为"上皮间质转化,干细胞,肿瘤/癌;epithelial-mesenchymal transition,Stem cell,tumor/cancer",共检索到文献1 249篇,最终纳入符合标准的文献50篇。结果与结论:上皮间质转化与干细胞分化和肿瘤细胞的发生、发展密切相关,在干细胞分化和肿瘤侵袭转移中均发现了上皮间质转化相关标志因子。上皮间质转化受多种调控因素的影响,而干细胞分化和肿瘤的发生发展也是多程序多步骤的复杂过程。虽然现在对上皮间质转化与这二者之间的发生及部分调节机制有了比较透彻的了解,但对整个复杂调控网络的了解还是远远不够的。如何更深入了解上皮间质转化的发生及调控机制网,以及如何更好地把研究成果安全有效地应用于临床预防、诊断及治疗,将会成为现在及未来大家共同的努力目标。
[Abstract]:Background: epithelial mesenchymal transformation is closely related to embryonic development, stem cell induction and differentiation, tissue repair, tumorigenesis and development. Objective: to review the role of epithelial mesenchymal transformation in stem cell induced differentiation and tumorigenesis. Methods: the relevant literatures of CNKI database and Pub Med database were searched by computer from 2001 to 2016. The key words were: "epithelial mesenchymal transformation, stem cell, tumor / carcinoma epithelial-mesenchymal transitiontionStem cell tumour cancer". A total of 1 249 papers were retrieved. Finally, 50 articles that met the criteria were included. Results & conclusion: epithelial mesenchymal transformation is closely related to stem cell differentiation and tumor cell development, and related markers of epithelial mesenchymal transformation have been found in stem cell differentiation and tumor invasion and metastasis. Epithelial mesenchymal transformation is affected by many regulatory factors, and stem cell differentiation and tumor development are complex processes. Although there is a thorough understanding of the occurrence and partial regulation mechanism between epithelial mesenchymal transformation and these two mechanisms, the understanding of the whole complex regulatory network is far from enough. How to better understand the mechanism of epithelial mesenchymal transformation and how to apply the research results safely and effectively to clinical prevention diagnosis and treatment will become the common goal of present and future.
【作者单位】：海南医学院;海南医学院附属医院;海南省人类生殖与遗传重点实验室;热带病转化医学教育部重点实验室;
【基金】：国家自然科学基金(81460034,81060175) 科技部国家国际科技合作专项项目(2014DFA30180) 海南省自然科学基金(812201) 海南省普通高等学校研究生创新科研课题(hys2015-61)~~
【分类号】：R730.2

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