162例局部晚期老年肺鳞状细胞癌患者预后因素分析
发布时间：2018-07-16 11:51
【摘要】：目的:对局部晚期老年肺鳞状细胞癌患者进行回顾性分析,确定影响预后的因素,预测生存期,寻求最佳治疗方式。方法:按纳入标准搜集2010年1月1日至2015年1月1日就诊于山西省肿瘤医院的老年肺鳞状细胞癌患者162例;对相关预后因素分别进行Kaplan-Meier单因素和Cox回归多因素分析;并对治疗相关不良反应进行对照。结果:162例患者中位年龄73.6岁,总体中位生存期为19.4月,1年生存率为71.0%,2年生存率为35.9%。Kaplan-Meier单因素分析示:年龄(χ2=7.94,P=0.005)、ECOG评分(χ2=42.12,P=0.000)、化放疗联合与否(χ2=14.99,P=0.000)是影响生存的预后因素。Cox回归多因素分析示:ECOG评分(HR=0.299,P=0.000,95%CI为0.193~0.462)、N分期(HR=0.645,P=0.026,95%CI为0.439~0.949)是影响预后的独立因素。治疗相关不良反应显示:化放疗联合治疗组在血液、消化、呼吸系统发生毒副反应的例数均高于单纯放疗组,尤其在白细胞(P=0.000),血小板(P=0.001)、消化道(P=0.000)和急性肺部炎症(P=0.005)的毒副反应经χ2检验具有统计学差异(P0.05)。结论:1.ECOG评分和N分期是影响未手术、局部晚期老年肺鳞状细胞癌患者生存期的独立预后因素。ECOG评分越低(0~1分),淋巴结转移的部位越少(N_(0-1)),生存期越长;反之,生存期越短。2.局部晚期老年肺鳞状细胞癌患者行化放疗联合治疗时,更易出现毒副反应。
[Abstract]:Objective: to determine the prognostic factors, predict survival and seek the best treatment for the elderly patients with locally advanced lung squamous cell carcinoma (LSCC). Methods: 162 elderly patients with lung squamous cell carcinoma from January 1, 2010 to January 1, 2015 were collected according to the inclusion criteria. Kaplan-Meier univariate analysis and Cox regression multivariate analysis were performed on the prognostic factors. The side effects of treatment were compared. Results the median age of 162 patients was 73.6 years old. The overall median survival time was 19.4 months, the 1-year survival rate was 71.0, and the 2-year survival rate was 35.9.Kaplan-Meier univariate analysis showed that age (蠂 ~ 22n = 7.94) and ECOG score (蠂 ~ 22.12 / P ~ 0.000), chemoradiotherapy and radiotherapy (蠂 ~ 214.99P _ 0.000) were prognostic factors of survival. Cox regression analysis showed that the score of w ECOG (HR0.299P0. 00095CI was 0.1930.462). Stage (HRN 0. 645) (CI = 0. 439 ~ 0. 949) is an independent prognostic factor. Treatment related adverse reactions showed that the number of adverse reactions in blood, digestion and respiratory system in the combined chemotherapy and radiotherapy group was higher than that in the radiotherapy alone group. The side effects of leukocytes (P0. 000), platelets (P0. 001), digestive tract (P0. 000) and acute pulmonary inflammation (P0. 005) were significantly different by 蠂 2 test (P0.05). Conclusion: 1. ECOG score and N stage are the independent prognostic factors of survival period in the elderly patients with locally advanced lung squamous cell carcinoma. The lower the score is (0 ~ 1 score), the less the location of lymph node metastasis is (N0-1), survival time is longer; conversely, the shorter the survival time is. 2. Patients with locally advanced lung squamous cell carcinoma (LSCC) are more likely to develop toxic side effects when combined chemotherapy and radiotherapy.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2
本文编号：2126301
[Abstract]:Objective: to determine the prognostic factors, predict survival and seek the best treatment for the elderly patients with locally advanced lung squamous cell carcinoma (LSCC). Methods: 162 elderly patients with lung squamous cell carcinoma from January 1, 2010 to January 1, 2015 were collected according to the inclusion criteria. Kaplan-Meier univariate analysis and Cox regression multivariate analysis were performed on the prognostic factors. The side effects of treatment were compared. Results the median age of 162 patients was 73.6 years old. The overall median survival time was 19.4 months, the 1-year survival rate was 71.0, and the 2-year survival rate was 35.9.Kaplan-Meier univariate analysis showed that age (蠂 ~ 22n = 7.94) and ECOG score (蠂 ~ 22.12 / P ~ 0.000), chemoradiotherapy and radiotherapy (蠂 ~ 214.99P _ 0.000) were prognostic factors of survival. Cox regression analysis showed that the score of w ECOG (HR0.299P0. 00095CI was 0.1930.462). Stage (HRN 0. 645) (CI = 0. 439 ~ 0. 949) is an independent prognostic factor. Treatment related adverse reactions showed that the number of adverse reactions in blood, digestion and respiratory system in the combined chemotherapy and radiotherapy group was higher than that in the radiotherapy alone group. The side effects of leukocytes (P0. 000), platelets (P0. 001), digestive tract (P0. 000) and acute pulmonary inflammation (P0. 005) were significantly different by 蠂 2 test (P0.05). Conclusion: 1. ECOG score and N stage are the independent prognostic factors of survival period in the elderly patients with locally advanced lung squamous cell carcinoma. The lower the score is (0 ~ 1 score), the less the location of lymph node metastasis is (N0-1), survival time is longer; conversely, the shorter the survival time is. 2. Patients with locally advanced lung squamous cell carcinoma (LSCC) are more likely to develop toxic side effects when combined chemotherapy and radiotherapy.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2
【参考文献】
相关期刊论文 前1条
1 吕远;姜昒;马春华;李金铎;王斌;孙立伟;穆宁;;重组人血管内皮抑制素静脉持续泵入联合窗口期动脉灌注化疗治疗晚期肺鳞癌的临床观察[J];中国肺癌杂志;2015年08期
，本文编号：2126301
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