吲哚菁绿联合亚甲蓝在早期乳腺癌前哨淋巴结活检术中的应用价值

发布时间：2018-07-23 11:09

【摘要】：目的探讨吲哚菁绿联合亚甲蓝作为淋巴示踪剂在早期乳腺癌前哨淋巴结活检术中的价值。方法将170例腋窝淋巴结阴性的早期乳腺癌患者随机分为联合组与亚甲蓝组各85例,分别接受吲哚菁绿联合亚甲蓝与单独使用亚甲蓝作为淋巴示踪剂,两组患者均行常规前哨淋巴结活检手术。手术切除的前哨淋巴结送冰冻检查及常规石蜡病理检查。结果联合组与亚甲蓝组前哨淋巴结检出率分别为98.8%(84/85)、95.3%(81/85),两组比较,P0.05。联合组共检出前哨淋巴结334枚,平均3.93枚/例;亚甲兰组检出淋巴结总数284枚,平均3.34枚/例,两组前哨淋巴结检出总数比较,P0.05。联合组检出腋窝淋巴结阳性19例,共检出转移淋巴结59枚,亚甲蓝组检出腋窝淋巴结阳性16例,转移淋巴结40枚。联合组检出的59枚转移性淋巴结中,全部被吲哚菁绿检出,但亚甲蓝仅检出36枚。结论吲哚菁绿联合亚甲蓝作为淋巴示踪剂有良好的可视性,检出前哨淋巴结数量和标记的腋淋巴结阳性数多于单用亚甲蓝法,在早期乳腺癌前哨淋巴结活检术中有较高价值。
[Abstract]:Objective to investigate the value of indocyanine green combined with methylene blue as lymphatic tracer in sentinel lymph node biopsy of early breast cancer. Methods 170 patients with early breast cancer with negative axillary lymph nodes were randomly divided into two groups: the combined group (85 cases) and the methylene blue group (85 cases). The patients received indocyanine green combined with methylene blue and methylene blue alone as lymphatic tracer. Routine sentinel lymph node biopsy was performed in both groups. Sentinel lymph node freezing and routine paraffin pathological examination were performed. Results the detection rate of sentinel lymph nodes in the combined group and methylene blue group was 98.8% (84 / 85) and 95.3% (81 / 85), respectively. 334 sentinel lymph nodes were detected in the combined group, with an average of 3.93 per case, and 284 lymph nodes were detected in the methylene blue group with an average of 3.34. The total number of sentinel lymph nodes detected in the two groups was higher than that in the two groups (P 0.05). In the combined group, 19 cases were positive for axillary lymph nodes, 59 were detected for metastatic lymph nodes, 16 were positive for axillary lymph nodes in methylene blue group, and 40 were metastatic lymph nodes. Of the 59 metastatic lymph nodes detected in the combined group, all were detected by indocyanine green, but only 36 by methylene blue. Conclusion Indocyanine green combined with methylene blue as a lymphatic tracer has good visibility. The number of sentinel lymph nodes and the positive number of labeled axillary lymph nodes are more than those of single methylene blue method, which is of great value in sentinel lymph node biopsy of early breast cancer.
【作者单位】：石河子大学医学院第一附属医院;
【基金】：新疆生产建设兵团卫生科技项目(2015501)
【分类号】：R737.9

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