宫颈癌患者人乳头瘤病毒与巨细胞病毒和单纯疱疹病毒Ⅱ型感染的相关性研究

发布时间：2018-07-24 08:29

【摘要】：目的探讨宫颈癌(CC)和单纯疱疹病毒Ⅱ型(HSVⅡ)、巨细胞病毒(HCMV)及16、18及35型人乳头瘤病毒(HPV)感染的关系,为CC的发病机制研究和防治工作提供科学参考。方法选取医院2013年2月-2015年2月接诊的130例宫颈疾病患者,按照患者宫颈病情不同,将64例患有良性宫颈疾病的患者归为良性组,66例CC患者归为CC组,另选取60例宫颈正常的健康女性作为对照组,比较3组HPV、HCMV、HSVⅡ检出率。结果对照组未检测出HPV 16、HPV18、HPV35阳性,CC组HCMV检出率分别为77.27%、74.24%、72.73%,HSVⅡ检出率分别为74.24%、72.73%、72.73%,阳性检出率在不同检测点均显著高于对照组和良性组,差异均有统计学意义(P0.05)。结论 HSVⅡ、HPV 16、HPV18、HCMV感染均能够提高CC发病率,其与CC的病情进展有重要关联,及早对HCMV、HSVⅡ、HPV 16、HPV18高危群体进行筛查有利于宫颈癌的诊断治疗。
[Abstract]:Objective to investigate the relationship between cervical cancer (CC) and herpes simplex virus type II (HSV II), cytomegalovirus (HCMV) and 16,18 and type 35 human papillomavirus (HPV) infection, and to provide a scientific reference for the study and prevention of the pathogenesis of CC. Methods selected 130 cases of cervical disease in the hospital in February 2013 in February 2013 according to the patient's cervix condition. 64 patients with benign cervical disease were classified as benign group, 66 CC patients were classified as group CC, and 60 healthy women were selected as control group, and 3 groups of HPV, HCMV, and HSV II detection rates were compared. The control group did not detect HPV 16, HPV18, HPV35 positive, CC group HCMV detection rates were 77.27%, 74.24%, 72.73%, HSV II detection rates respectively The positive rates of 74.24%, 72.73% and 72.73% were significantly higher than those in the control group and the benign group, and the difference was statistically significant (P0.05). Conclusion HSV II, HPV 16, HPV18, HCMV infection can improve the incidence of CC, and it has an important association with the progression of CC. It is beneficial to screen early HCMV, HSV II, HPV 16, HPV18 high-risk group. Diagnosis and treatment of cervical cancer.
【作者单位】：南阳医专第一附属医院妇产科;南阳医学高等专科学校临床医学系妇产科教研室;
【分类号】：R737.33

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