循环microRNAs的外泌形成机制及其对乳腺癌侵袭和转移的影响

发布时间：2018-07-24 21:12

【摘要】：目前乳腺癌的临床诊疗主要依赖影像学和相对较少的预后/预测指标(如雌激素受体、孕激素受体、HER2等).这些生物标志物主要是基于原发肿瘤病灶的生物学检测,可用于转移或复发的检测指标很少,尤其是在切除肿瘤原发灶后,复发监测很困难.循环cell-free microRNAs(circulating cf-miRNAs,或简称circulating miRNAs)的发现为改变现有乳腺癌临床诊疗模式提供了可能.Cell-free miRNA通过外泌体、微囊或转运蛋白的主动外泌机制,可能在循环miRNA的形成中起着重要作用.Cell-free miRNA特别是circulating miRNA不仅自身可以作为信号分子影响肿瘤细胞和组织微环境,而且还可以与其他信号通路发生交互通讯来调控肿瘤部位新生血管的形成和肿瘤细胞表型的上皮-间质转换,影响乳腺癌的侵袭和转移.本文综述了循环miRNA的特征与分泌机制,特别是乳腺癌相关的循环miRNA参与作为一种液体活检生物标志物在乳腺癌诊断、预后评价和疗效评估的临床意义.
[Abstract]:At present, the clinical diagnosis and treatment of breast cancer is mainly dependent on imaging and relatively few prognostic / prognostic indicators (such as estrogen receptor, progesterone receptor, HER2, etc.). These biomarkers are based on biological detection of primary tumor lesions, which can be used to detect rare metastasis or recurrence, especially after tumor resection. Detection is difficult. The discovery of cyclic cell-free microRNAs (circulating cf-miRNAs, or circulating miRNAs) provides an active exocrine mechanism for the possible change of the existing clinical diagnosis and treatment model of breast cancer by.Cell-free miRNA, which may play an important role in the formation of circulating miRNA, and may play an important role in the formation of.Cell-free miRNA. Circulating miRNA can not only affect the tumor cells and tissue microenvironment as a signal molecule, but also interact with other signaling pathways to regulate the formation of neovascularization in the tumor site and the epithelial mesenchymal transition of the tumor cell phenotype, affecting the invasion and metastasis of breast cancer. This article reviews the circulating miRNA. Characteristics and secretory mechanisms, especially breast cancer related circulating miRNA, are involved in the clinical significance of a liquid biopsy biomarker in the diagnosis of breast cancer, the evaluation of prognosis, and the evaluation of the efficacy of the breast cancer.
【作者单位】：潍坊医学院分子肿瘤学实验室;潍坊医学院附属医院;
【基金】：国家自然科学基金(81472489) 山东省科技发展计划(2014GGB14403)资助项目~~
【分类号】：R737.9

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