中药注射液联合含奥沙利铂化疗方案治疗大肠癌的网状Meta分析
发布时间：2018-07-28 17:17
【摘要】：目的:采用网状Meta分析评价中药注射液(CMI)联合含奥沙利铂(L-OHP)化疗方案治疗大肠癌的疗效和安全性,为临床提供循证参考。方法:计算机检索相关期刊论文,万方数据库,中国生物医学文献数据库,中文科技期刊数据库,Pub Med,Embase(各数据库建库起至2016年11月20日),收集中药注射液联合含L-OHP化疗方案对比单纯含L-OHP化疗方案治疗大肠癌的随机对照试验(RCT),提取资料并依据改良的Jadad量表进行质量评价后,采用ADDIS软件进行网状Meta分析。结果:最终纳入14种CMI,64项RCTs,合计5 081例患者。纳入文献有4篇高质量。网状Meta分析结果显示:(1)对比单纯化疗,3种CMI联合含L-OHP的化疗方案能提高临床有效率(WHO标准),7种CMI能提高患者生活质量、降低白细胞减少,6种CMI能减少恶心呕吐,4种CMI能减少周围神经毒性,差异有统计学意义;(2)在降低周围神经毒性方面,黄芪注射液优于艾迪注射液,参麦注射液优于复方苦参注射液、康艾注射液,差异有统计学意义,其余两两之间的对比差异无统计学意义。结论:目前证据支持中药注射液联合含L-OHP化疗方案治疗大肠癌优于单纯化疗。受纳入文献方法学质量限制,该研究有待大样本及更多高质量的RCT进一步验证。
[Abstract]:Objective: to evaluate the efficacy and safety of traditional Chinese medicine injection (CMI) combined with oxaliplatin (L-OHP) in the treatment of colorectal cancer by reticular Meta analysis. Methods: the full text database of Chinese periodicals, the database of Wanfang and the database of Chinese biomedical literature were searched by computer. The Chinese sci-tech journal database Pub Medembase (each database was established until November 20, 2016) was used to collect the data of (RCT), extracted from Chinese medicine injection combined with chemotherapy regimen containing L-OHP in the randomized controlled trial of treatment of colorectal cancer compared with the chemotherapy regimen containing L-OHP alone. According to the quality evaluation of the modified Jadad scale, ADDIS software was used to analyze the mesh Meta. Results: 64 items of RCTs of 14 CMIs were included, totally 5081 patients. Four articles of high quality were included in the literature. The results of reticular Meta analysis showed that: (1) the clinical effective rate (WHO standard) and 7 kinds of CMI could improve the quality of life (QOL) of the patients compared with the chemotherapy regimen of 3 CMI and L-OHP alone. Six kinds of CMI can reduce nausea and vomiting and 4 kinds of CMI can reduce peripheral nerve toxicity. (2) Astragalus injection is better than Aidi injection in reducing peripheral neurotoxicity. Shenmai injection was superior to compound Sophora flavescens injection and Kangai injection, the difference was statistically significant. Conclusion: the evidence supports that the combination of traditional Chinese medicine injection and L-OHP regimen is superior to chemotherapy alone in the treatment of colorectal cancer. Limited by the quality of methodology included in the literature, this study needs to be further validated by large samples and more high quality RCT.
【作者单位】： 广州中医药大学第四临床医学院深圳市中医院;
【基金】：深圳市科技计划项目(JCYJ20150401163247231)
【分类号】：R735.34
本文编号：2151016
[Abstract]:Objective: to evaluate the efficacy and safety of traditional Chinese medicine injection (CMI) combined with oxaliplatin (L-OHP) in the treatment of colorectal cancer by reticular Meta analysis. Methods: the full text database of Chinese periodicals, the database of Wanfang and the database of Chinese biomedical literature were searched by computer. The Chinese sci-tech journal database Pub Medembase (each database was established until November 20, 2016) was used to collect the data of (RCT), extracted from Chinese medicine injection combined with chemotherapy regimen containing L-OHP in the randomized controlled trial of treatment of colorectal cancer compared with the chemotherapy regimen containing L-OHP alone. According to the quality evaluation of the modified Jadad scale, ADDIS software was used to analyze the mesh Meta. Results: 64 items of RCTs of 14 CMIs were included, totally 5081 patients. Four articles of high quality were included in the literature. The results of reticular Meta analysis showed that: (1) the clinical effective rate (WHO standard) and 7 kinds of CMI could improve the quality of life (QOL) of the patients compared with the chemotherapy regimen of 3 CMI and L-OHP alone. Six kinds of CMI can reduce nausea and vomiting and 4 kinds of CMI can reduce peripheral nerve toxicity. (2) Astragalus injection is better than Aidi injection in reducing peripheral neurotoxicity. Shenmai injection was superior to compound Sophora flavescens injection and Kangai injection, the difference was statistically significant. Conclusion: the evidence supports that the combination of traditional Chinese medicine injection and L-OHP regimen is superior to chemotherapy alone in the treatment of colorectal cancer. Limited by the quality of methodology included in the literature, this study needs to be further validated by large samples and more high quality RCT.
【作者单位】： 广州中医药大学第四临床医学院深圳市中医院;
【基金】：深圳市科技计划项目(JCYJ20150401163247231)
【分类号】：R735.34
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