旋复花代赭石汤联合西药治疗肿瘤恶病质恶心呕吐的临床研究
发布时间：2018-07-28 18:09
【摘要】：目的探讨旋复花代赭石汤联合甲氧氯普胺和氟哌啶醇对肿瘤恶病质恶心呕吐的效果。方法采用前瞻性随机对照试验,将286例肿瘤恶病质恶心呕吐患者随机分为甲旋二联组(n=73)、甲氟二联组(n=75)、甲氟旋三联组(n=68)和对照组(甲氧氯普胺组,n=70)。采用WHO抗癌药副作用恶心呕吐分级标准、恶心呕吐及干呕指数评价量表(INVR)和多维度疲乏症状量表-简表(MFSI-SF)分别对患者用药前、2周、8周进行跟踪测评。结果三联组在用药2、8周时止吐作用有效率分别为76.5%和94.1%,显著高于对照组和二联组(P0.05);三联组在用药2周时INVR评分显著低于对照组和甲旋二联组(P0.05),但与甲氟二联组无统计学差异;三联组在用药8周时INVR和MFSI-SF评分均显著低于对照组和二联组(P0.05)。结论旋复花代赭石汤联合西药三联用药方案对肿瘤恶病质恶心呕吐患者,显示了长期稳定的止吐效果,且能有效改善患者疲乏,值得临床推广。
[Abstract]:Objective to investigate the effect of Xinfen Huadai Zhe Shi decoction combined with metoclopramide and haloperidol on the nausea and vomiting of tumor cachexia. Methods in a prospective randomized controlled trial, 286 patients with nausea and vomiting of cachexia were randomly divided into three groups: medroxine group (n = 73), meflurane group (n = 75), trimeflurane group (n = 68) and control group (n = 70). WHO, (INVR) and MFSI-SF were used to measure the adverse effects, nausea and vomiting. The patients were followed up for 2 weeks and 8 weeks before treatment. Results the effective rate of antiemetic effect in the triple group was 76.5% and 94.1% respectively, which was significantly higher than that in the control group and the combined group (P0.05), and the INVR score in the triple group was significantly lower than that in the control group and the methyl-circumflex group at 2 weeks (P0.05), but there was no significant difference between the triple group and the meflorine group. The scores of INVR and MFSI-SF in the triple group were significantly lower than those in the control group and the second group at 8 weeks (P0.05). Conclusion Xinfu Huadai Zhe Shi decoction combined with western medicine has a long-term and stable antiemetic effect on patients with cachexia, and it can effectively improve the fatigue of patients. It is worth popularizing in clinic.
【作者单位】： 郑州市第九人民医院姑息(缓和)治疗暨安宁疗护中心;郑州市第一人民医院;郑州大学护理学院;郑州大学第一附属医院;河南省人民医院;
【基金】：河南省科技厅重点科技攻关项目(142102310140) 河南省医学科技攻关计划(201204139) 河南省青年卫生科技创新人才项目 河南省郑州市科技攻关项目(2PPTSF302);河南省郑州市科技攻关项目(20120821) 河南省郑州市卫生局2011博士创业基金项目
【分类号】：R730.5
本文编号：2151175
[Abstract]:Objective to investigate the effect of Xinfen Huadai Zhe Shi decoction combined with metoclopramide and haloperidol on the nausea and vomiting of tumor cachexia. Methods in a prospective randomized controlled trial, 286 patients with nausea and vomiting of cachexia were randomly divided into three groups: medroxine group (n = 73), meflurane group (n = 75), trimeflurane group (n = 68) and control group (n = 70). WHO, (INVR) and MFSI-SF were used to measure the adverse effects, nausea and vomiting. The patients were followed up for 2 weeks and 8 weeks before treatment. Results the effective rate of antiemetic effect in the triple group was 76.5% and 94.1% respectively, which was significantly higher than that in the control group and the combined group (P0.05), and the INVR score in the triple group was significantly lower than that in the control group and the methyl-circumflex group at 2 weeks (P0.05), but there was no significant difference between the triple group and the meflorine group. The scores of INVR and MFSI-SF in the triple group were significantly lower than those in the control group and the second group at 8 weeks (P0.05). Conclusion Xinfu Huadai Zhe Shi decoction combined with western medicine has a long-term and stable antiemetic effect on patients with cachexia, and it can effectively improve the fatigue of patients. It is worth popularizing in clinic.
【作者单位】： 郑州市第九人民医院姑息(缓和)治疗暨安宁疗护中心;郑州市第一人民医院;郑州大学护理学院;郑州大学第一附属医院;河南省人民医院;
【基金】：河南省科技厅重点科技攻关项目(142102310140) 河南省医学科技攻关计划(201204139) 河南省青年卫生科技创新人才项目 河南省郑州市科技攻关项目(2PPTSF302);河南省郑州市科技攻关项目(20120821) 河南省郑州市卫生局2011博士创业基金项目
【分类号】：R730.5
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