长链非编码RNA MALAT-1:一种预测肿瘤转移的潜在生物标志物

发布时间：2018-08-01 18:13

【摘要】：最近,越来越多的研究表明,长链非编码RNA MALAT-1在许多恶性肿瘤组织或细胞中均处于高表达状态,并与肿瘤转移关系密切。Meta分析是根据现有的研究现状对具有相同目的且相互独立的多个研究结果进行系统评价和定量分析的一种方法。在此次研究中,我们利用计算机检索维普数据库、万方数据库、CNKI数据库和Pub Med数据库,检索时间截止至2016年6月,收集所有符合纳入标准的相关研究资料。按照严格的纳入和排除标准分类整理、筛选剔除后,运用统计分析专用软件Review Manger 5.3对符合标准的研究进行Meta分析,系统评价长链非编码RNA MALAT-1的表达水平与肿瘤淋巴结转移(LNM)及远端转移(DM)之间的关系,探索MALAT-1是否具有成为预测肿瘤转移的分子标志物的潜能。初筛共检索出292篇文献,其中符合纳入标准的有9篇,应用固定效应模型或随机效应模型进行分析。研究结果表明,与肿瘤患者中长链非编码RNA MALAT-1低表达组相比,MALAT-1高表达组与肿瘤淋巴结转移(OR=2.10,95%CI:1.29~3.43,p0.05)和远端转移(OR=2.22,95%CI:1.29~3.82,p0.05)之间的关系密切。这说明MALAT-1的表达水平异常升高,肿瘤病人发生淋巴结转移和远端转移的危险性越大,表明长链非编码RNA MALAT-1具有成为预测不同类型肿瘤转移的分子标志物的潜能。
[Abstract]:Recently, more and more studies have shown that long chain noncoding RNA MALAT-1 is highly expressed in many malignant tumor tissues or cells. Meta-analysis, which is closely related to tumor metastasis, is a method for systematic evaluation and quantitative analysis of multiple research results with the same purpose and independent of each other according to the present research situation. In this study, we used computer to retrieve Weip database, Wanfang database and Pub Med database. The retrieval time is up to June 2016, and we collect all relevant research data that meet the inclusion criteria. According to the strict classification of inclusion and exclusion criteria, after screening and culling, Meta analysis was carried out on the research in accordance with the standard by using the special software Review Manger 5.3 for statistical analysis. The relationship between the expression of long chain noncoding RNA MALAT-1 and lymph node metastasis (LNM) and distal metastatic (DM) (DM) was systematically evaluated to explore the potential of MALAT-1 as a molecular marker for predicting tumor metastasis. A total of 292 articles were retrieved, 9 of which met the inclusion criteria. The fixed effect model or random effect model was used to analyze the results. The results showed that the high expression of MALAT-1 was closely related to lymph node metastasis (OR 2.10 ~ 95 CI: 1.29 ~ 3.43 p0.05) and distant metastasis (OR2.2295 CI: 1.293.82p0.05) compared with the low expression group of long chain non-coding RNA MALAT-1. This indicates that the expression of MALAT-1 is abnormally high and the risk of lymph node metastasis and distal metastasis is higher in tumor patients. It is suggested that long chain noncoding RNA MALAT-1 has the potential to be a molecular marker for predicting different types of tumor metastasis.
【作者单位】：广州医科大学医学遗传学与细胞生物学教研室;
【基金】：国家自然科学基金项目(81102159;81302378) 广东省自然科学基金项目(2016A030313567) 广州市教育局广州市属高校“羊城学者”科研项目(12A010D) 广州市科技计划项目(201607010035) 广东高校优秀青年创新人才培养计划项目(育苗工程2013LYM0072)共同资助
【分类号】：R73-37

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