淋巴结跳跃转移在可切除胸段食管鳞癌中的预后价值

发布时间：2018-08-02 09:33

【摘要】：目的:本研究旨在探讨淋巴结跳跃转移在食管鳞癌中的发生率,确定影响食管鳞癌淋巴结跳跃转移的危险因素及评估淋巴结跳跃转移在胸段食管鳞状细胞癌患者中的预后价值。方法:收集了2011年1月1日到2013年12月31日之间在山东省肿瘤医院接受食管癌完全切除术的113名淋巴结阳性的患者。结果:淋巴结跳跃转移在全组的发生率为43.4%(49/113)。淋巴结跳跃转移组的中位生存时间和5年生存率分别为18.0个月和3.0%,非淋巴结跳跃转移组的中位生存时间和5年生存率分别为31.0个月和30.0%(P0.0001)。性别(P=0.027)、年龄(P=0.008)和肿瘤分化程度(P=0.026)与淋巴结跳跃转移的发生有关。肿瘤位置(P=0.014),T分期(P=0.000)、N分期(P=0.000)和跳跃转移(P=0.001)是食管鳞癌独立的预后影响因素。结论:跳跃是食管鳞癌常见的淋巴结转移方式之一,发生淋巴结跳跃转移者其预后相对较差。
[Abstract]:Objective: to investigate the incidence of leaping lymph node metastasis in esophageal squamous cell carcinoma, to determine the risk factors of lymph node jumping metastasis and to evaluate the prognostic value of jump lymph node metastasis in thoracic esophageal squamous cell carcinoma. Methods: 113 patients underwent complete resection of esophageal carcinoma from January 1, 2011 to December 31, 2013 were collected. Results: the incidence of lymph node jump metastasis was 43.4% (49 / 113). The median survival time and 5-year survival rate were 18.0 months and 3.0 months in the lymph node jumping metastasis group, and 31.0 months and 30.0% in the non-lymph node jumping metastasis group (P 0.0001). Sex (P0. 027), age (P0. 008) and tumor differentiation (P0. 026) were associated with lymph node jumping metastasis. Tumor location (P0. 014) T stage (P0. 000) and skip metastasis (P0. 001) were independent prognostic factors of esophageal squamous cell carcinoma. Conclusion: jumping is one of the most common lymph node metastases in esophageal squamous cell carcinoma.
【学位授予单位】：济南大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.1

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