磁共振引导乳腺癌热消融治疗的温度成像方法研究
发布时间：2018-08-04 15:52
【摘要】：磁共振引导的乳腺微波热消融治疗是一种重要的微创介入治疗方式,由于有着创伤小、恢复快等优势,它正逐渐成为治疗乳腺癌的有效手段。在微创介入治疗中,需要解决对目标组织施加热量的控制和对手术部位的温度监控等问题,因此必须对治疗过程进行实时监控包括对目标组织精确定位和温度监控,以提高手术的成功率。 在磁共振引导乳腺微波消融手术过程中,温度成像方法可以算出被消融区域的准确温度。虽然目前国内外已经有很多种温度成像方法,但是由于乳腺组织自身的特殊性,需要对已有的温度成像方法加以改进,以消除乳腺组织中大量的脂肪组织对温度测量的准确性的影响：而在同时含有水和脂肪的组织中,含有水的组织的测温结果会受到温度变化导致的周围脂肪组织的磁化率变化的影响,引起测温误差。因此,需要一种新的测温方法或者温度成像优化方法减小磁化率变化对测温准确性的影响。 针对上述问题,本文提出了一种新的基于磁化率变化的温度成像优化方法。首先使用最基本的温度成像方法求出热消融区域的温度；然后针对乳腺组织的特异性,使用水脂分离的温度成像方法计算温度,同时借助水和脂肪磁化率变化的差异性对温度进行修正；最后将温度差作为评估温度修正算法优劣的指标。 最后仿真实验结果表明,对于包含水脂两种组织的热消融模型,在微波消融输入功率为15W,微波消融时间为300s的时候,本算法的综合修正效果最好。上述结果证明了本算法的正确性以及可行性,适用于任何含有水和脂肪两种物质的组织。
[Abstract]:Magnetic resonance guided microwave ablation is an important method of minimally invasive interventional therapy. Because of its advantages of less trauma and faster recovery, it is becoming an effective method for the treatment of breast cancer. In the minimally invasive interventional therapy, it is necessary to solve the problems of applying heat to the target tissue and monitoring the temperature of the operation site, so it is necessary to monitor the treatment process in real time, including the precise location and temperature monitoring of the target tissue. In order to improve the success rate of operation. In the course of microwave ablation of breast guided by magnetic resonance imaging, the accurate temperature of the ablated area can be calculated by thermography. Although there are many kinds of temperature imaging methods at home and abroad, because of the particularity of mammary tissue itself, the existing thermal imaging methods need to be improved. To eliminate the effect of a large amount of adipose tissue in breast tissue on the accuracy of temperature measurements: in tissues that contain both water and fat, The temperature measurement results of tissues containing water will be affected by the change of magnetic susceptibility of the surrounding adipose tissue caused by the temperature change, resulting in the temperature measurement error. Therefore, a new temperature measurement method or a temperature imaging optimization method is needed to reduce the influence of magnetic susceptibility on the accuracy of temperature measurement. In order to solve the above problems, a new optimization method of temperature imaging based on magnetic susceptibility variation is proposed in this paper. First, the temperature of the ablation area is calculated by using the most basic temperature imaging method, and then the temperature is calculated by using the water-lipid separation temperature imaging method for the specificity of the breast tissue. At the same time, the temperature is corrected by the difference of the magnetic susceptibility of water and fat. Finally, the temperature difference is used as the index to evaluate the temperature correction algorithm. Finally, the simulation results show that the proposed algorithm has the best comprehensive effect when the microwave ablation input power is 15W and the microwave ablation time is 300s for the thermal ablation model with two kinds of tissues including water and fat. The above results prove the correctness and feasibility of this algorithm, and it is suitable for any tissue containing water and fat.
【学位授予单位】：中国科学技术大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.9
本文编号：2164368
[Abstract]:Magnetic resonance guided microwave ablation is an important method of minimally invasive interventional therapy. Because of its advantages of less trauma and faster recovery, it is becoming an effective method for the treatment of breast cancer. In the minimally invasive interventional therapy, it is necessary to solve the problems of applying heat to the target tissue and monitoring the temperature of the operation site, so it is necessary to monitor the treatment process in real time, including the precise location and temperature monitoring of the target tissue. In order to improve the success rate of operation. In the course of microwave ablation of breast guided by magnetic resonance imaging, the accurate temperature of the ablated area can be calculated by thermography. Although there are many kinds of temperature imaging methods at home and abroad, because of the particularity of mammary tissue itself, the existing thermal imaging methods need to be improved. To eliminate the effect of a large amount of adipose tissue in breast tissue on the accuracy of temperature measurements: in tissues that contain both water and fat, The temperature measurement results of tissues containing water will be affected by the change of magnetic susceptibility of the surrounding adipose tissue caused by the temperature change, resulting in the temperature measurement error. Therefore, a new temperature measurement method or a temperature imaging optimization method is needed to reduce the influence of magnetic susceptibility on the accuracy of temperature measurement. In order to solve the above problems, a new optimization method of temperature imaging based on magnetic susceptibility variation is proposed in this paper. First, the temperature of the ablation area is calculated by using the most basic temperature imaging method, and then the temperature is calculated by using the water-lipid separation temperature imaging method for the specificity of the breast tissue. At the same time, the temperature is corrected by the difference of the magnetic susceptibility of water and fat. Finally, the temperature difference is used as the index to evaluate the temperature correction algorithm. Finally, the simulation results show that the proposed algorithm has the best comprehensive effect when the microwave ablation input power is 15W and the microwave ablation time is 300s for the thermal ablation model with two kinds of tissues including water and fat. The above results prove the correctness and feasibility of this algorithm, and it is suitable for any tissue containing water and fat.
【学位授予单位】：中国科学技术大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R737.9
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