血液系统恶性疾病中巨噬细胞的研究进展

发布时间：2018-08-05 09:24

【摘要】：巨噬细胞是微环境中重要成员,其表型、功能具有很强的异质性;近年的研究不仅揭示了稳态条件下不同亚群的形态、表型及功能特点,而且逐步阐明疾病状态下巨噬细胞的变化及作用机制.肿瘤微环境中的巨噬细胞称为肿瘤相关巨噬细胞(T A M s),参与肿瘤增殖、血管生成、浸润、转移及化疗抵抗.在血液系统恶性疾病中,巨噬细胞广泛浸润到淋巴瘤、骨髓瘤、白血病等恶性细胞累及的组织中,被恶性微环境异常活化,获得了特异的活化表型,并参与疾病进展.在淋巴瘤、骨髓瘤中习惯沿用T A M s的名称;在白血病中其名称引申为白血病相关巨噬细胞、急性白血病相关巨噬细胞或者"保姆样细胞".本文综述了血液系统恶性疾病中巨噬细胞的研究进展.
[Abstract]:Macrophages are important members of microenvironment, their phenotypes and functions are highly heterogeneous. Recent studies have not only revealed the morphological, phenotypic and functional characteristics of different subpopulations under steady state conditions, Furthermore, the changes of macrophages and the mechanism of their action were clarified gradually under the condition of disease. Macrophages in tumor microenvironment are called tumor associated macrophages (T A M s),) involved in tumor proliferation, angiogenesis, invasion, metastasis and chemotherapeutic resistance. In hematological malignancies, macrophages are widely infiltrated into tissues involving lymphoma, myeloma, leukemia and other malignant cells, which are activated by malignant microenvironment, obtain specific activated phenotypes, and participate in the progression of the disease. In lymphoma, myeloma is used to use the name T A M s; in leukemia, its name extends to leukaemia associated macrophages, acute leukemia associated macrophages or "nanny like cells." This paper reviews the advances in the study of macrophages in malignant diseases of the blood system.
【作者单位】：中国医学科学院&北京协和医学院血液病医院(血液学研究所)实验血液学国家重点实验室;
【基金】：国家自然科学基金(批准号:81370634,81570153) 天津市自然科学基金(批准号:17JCZDJC35000) 中国医学科学院医学与健康科技创新工程(批准号:2016-I2M-2-006)资助
【分类号】：R733

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