初始可切除的结直肠癌肝转移术后早期复发的危险因素
发布时间：2018-08-07 13:39
【摘要】：背景:结直肠癌肝转移患者肝切除术后的复发是影响患者总体生存的重要原因。在肝切除术后2年内,超过一半的患者将会复发。其中大部分是在术后6月内复发,传统上称为早期复发;最新的研究认为将早期复发的时间定义为8个月更为合理。本研究分析初始可切除的结直肠癌肝转移术后早期复发的危险因素。方法:回顾性分析浙江大学附属第二医院自2007年2月至2016年5月收治的90例患结直肠癌肝转移,肝脏转移灶经评估为初始可切除并且接受转移灶切除术的患者。收集临床资料,单因素分析用t检验与χ2检验,多因素分析使用logistic回归分析;非正态分布资料用Wilcoxon秩和检验;COX回归分析绘制RFS曲线。结果:单因素分析结果显示:CA199200ng/ml、肝脏转移灶数目≥3个与CRLM患者早期复发有关(P0.05)。患者的性别、年龄、原发灶的部位、T分期、淋巴结转移、术前CEA水平、肝转移是否分布肝两叶、转移灶最大径是否≥5cm、同时性肝转移还是异时性肝转移、是否行新辅助化疗、术前化疗评估、是否术中B超探查、是否联合术中射频均与其早期复发无相关(P0.05)。结论:将早期复发的时间定义为8个月的前提下,CA199200ng/ml、肝脏转移灶数目≥3个是初始可切除的结直肠癌肝转移术后早期复发的危险因素,并且是独立危险因素。
[Abstract]:Background: recurrence after hepatectomy in patients with liver metastases from colorectal cancer is an important cause of overall survival. Within 2 years after hepatectomy, more than half of the patients will recur. Most of them recrudesce within 6 months after operation, which is traditionally called early recurrence. The latest study suggests that it is more reasonable to define the time of early recurrence as 8 months. This study analyzed the risk factors for early recurrence of liver metastases from colorectal cancer with initial resectability. Methods: 90 patients with liver metastasis from February 2007 to May 2016 in the second affiliated Hospital of Zhejiang University were retrospectively analyzed. The liver metastases were evaluated as initially resectable and resected. Clinical data were collected. T test and 蠂 2 test were used for univariate analysis, logistic regression analysis was used for multivariate analysis, and RFS curve was drawn by Wilcoxon rank sum test Cox regression analysis for non-normal distribution data. Results: univariate analysis showed that the number of liver metastases 鈮，
本文编号：2170193
[Abstract]:Background: recurrence after hepatectomy in patients with liver metastases from colorectal cancer is an important cause of overall survival. Within 2 years after hepatectomy, more than half of the patients will recur. Most of them recrudesce within 6 months after operation, which is traditionally called early recurrence. The latest study suggests that it is more reasonable to define the time of early recurrence as 8 months. This study analyzed the risk factors for early recurrence of liver metastases from colorectal cancer with initial resectability. Methods: 90 patients with liver metastasis from February 2007 to May 2016 in the second affiliated Hospital of Zhejiang University were retrospectively analyzed. The liver metastases were evaluated as initially resectable and resected. Clinical data were collected. T test and 蠂 2 test were used for univariate analysis, logistic regression analysis was used for multivariate analysis, and RFS curve was drawn by Wilcoxon rank sum test Cox regression analysis for non-normal distribution data. Results: univariate analysis showed that the number of liver metastases 鈮，
本文编号：2170193
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