异基因造血干细胞移植后移植物抗白血病效应与移植物抗宿主病分离方法的研究现状

发布时间：2018-08-08 19:57

【摘要】：背景:异基因造血干细胞移植的本质是免疫细胞的移植,其治疗作用主要依靠移植物抗白血病效应,但其伴随的移植物抗宿主病增加了患者的死亡率,影响疗效。目前研究者提出了多种减轻移植物抗宿主病同时增强移植物抗白血病效应的方法,但各有优缺点及争议点,故对两者之间的关系及分离方法尚需进一步深入的研究。目的:综述异基因造血干细胞移植后减轻移植物抗宿主病而加强或不降低移植物抗白血病效应的研究现状。方法:由第一作者检索万方、CNKI、Pub Med数据库,检索时间为2000至2016年,英文检索词为"hematopoietic stem cell transplantation,graft versus leukemia,graft-versus-host disease,donor lymphocyte infusion,regulatory T cell,natural killer cell,mesenchymal stem cell",查阅近年增强移植物抗白血病效应及减低移植物抗宿主病的相关文献。结果与结论:最终纳入42篇文献。目前有关移植物抗白血病效应和移植物抗宿主病的关系及各自的发生机制仍不十分明确,有关两者分离方法虽多,但各有优缺点及争议点,尚未有统一的最优方案,需要进一步研究。
[Abstract]:Background: the essence of allogeneic hematopoietic stem cell transplantation (HSCT) is immune cell transplantation. The therapeutic effect of allogeneic hematopoietic stem cell transplantation mainly depends on the graft versus leukemia effect, but the associated graft versus host disease increases the mortality of patients and affects the curative effect. At present, many methods have been proposed to reduce graft-versus-host disease and enhance graft-versus-leukemia effect, but each has its own advantages and disadvantages and controversial points, so the relationship between the two and the separation methods need to be further studied. Objective: to review the current research status of allogeneic hematopoietic stem cell transplantation (HSCT) to alleviate graft-versus-host disease (GVHD) and to enhance or not reduce GVL effect. Methods: the Med database was searched by the first author from 2000 to 2016. The key word was "hematopoietic stem cell transplantation/ graft versus leukemiagraft-versus-host disease donor lymphocyte infusionated T cell natural killer cell mesenchymal stem cell". The literature on enhancing graft versus leukemia effect and reducing graft versus host disease in recent years was reviewed. Results & conclusion: 42 articles were included. At present, the relationship between graft versus leukemia and graft-versus-host disease and their respective mechanisms are not very clear. Although there are many methods for separating the two, they have their own advantages, disadvantages and controversial points, and there is not yet a unified optimal scheme. Further study is needed.
【作者单位】：新疆医科大学第一附属医院血液病中心;新疆维吾尔自治区血液病研究所;
【基金】：国家自然科学基金(81060050)~~
【分类号】：R457.7;R733.7

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