rhG-GSF联合抗菌药物对急性白血病化疗后中性粒细胞缺乏合并感染患者血清炎症因子的影响

发布时间：2018-08-13 20:48

【摘要】：目的探讨重组人粒细胞刺激因子(rhG-CSF)联合抗菌药物对急性白血病化疗后中性粒细胞缺乏合并感染患者血清炎症因子的影响,为进行白血病化疗后中性粒细胞缺乏合并感染的治疗提供参考。方法选取2016年1月-12月期间住院的急性白血病化疗后中性粒细胞缺乏合并感染的患者60例,随机分为联合组与对照组,每组30例,两组患者均给予抗菌药物治疗,联合组联合rhG-GSF治疗;观察两组患者临床指标。结果联合组中性粒细胞恢复正常时间、体温恢复正常时间、抗菌药物使用时间短于对照组,差异有统计学意义(P0.05);治疗3d后,中性粒细胞高于治疗前(P0.05),PCT、CRP、IL-6低于治疗前(P0.05),且以上指标水平联合组改善优于对照组(P0.05)。结论 rhG-GSF联合抗菌药物治疗急性白血病化疗后中性粒细胞缺乏合并感染有助于快速改善炎症反应,缩短症状改善时间。
[Abstract]:Objective to investigate the effect of recombinant human granulocyte stimulating factor (rhG-CSF) combined with antimicrobial agents on serum inflammatory factors in patients with neutrophil deficiency and infection after chemotherapy in acute leukemia. To provide a reference for the treatment of neutropenia with infection after chemotherapy for leukemia. Methods from January to December 2016, 60 patients with neutropenia and infection after chemotherapy in acute leukemia were randomly divided into combined group and control group with 30 cases in each group. The patients in both groups were treated with antimicrobial agents. The combined group combined with rhG-GSF was used to observe the clinical indexes of the two groups. Results the neutrophil recovery time and body temperature recovery time in the combined group were shorter than those in the control group (P0.05). The level of neutrophil was higher than that before treatment (P0.05), and the level of IL-6 was lower than that before treatment (P0.05), and the improvement of the above index level in the combined group was better than that in the control group (P0.05). Conclusion rhG-GSF combined with antimicrobial agents in the treatment of neutropenia complicated with infection after chemotherapy in acute leukemia is helpful to improve the inflammatory reaction and shorten the time of symptom improvement.
【作者单位】：温州市温州医科大学附属第二医院血液肿瘤科;温州市温州医科大学附属第二医院心血管内科;温州市温州医科大学附属第二医院感染内科;
【分类号】：R733.71

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