lncRNAs在淋巴造血系统肿瘤中的研究进展
发布时间：2018-08-17 14:08
【摘要】：长链非编码RNAs(long noncoding RNAs,lnc RNAs)是长度≥200个核苷酸的非蛋白编码转录子。多数lnc RNAs在肿瘤组织中显示致癌基因的作用,通过影响肿瘤细胞的增生、迁移、浸润和转移促进肿瘤的发生发展;部分lnc RNAs已成为特定肿瘤的诊断及预后标志物。对其表达、功能及机制的研究成为当前肿瘤研究的热点,但多集中于上皮源性肿瘤。本文旨在对lnc RNAs在淋巴造血系统肿瘤中的研究进展进行综述。
[Abstract]:Long chain noncoding RNAs (long noncoding RN Aslnc RNAs is a nonprotein encoded transcript with a length of more than 200 nucleotides. Most of lnc RNAs show the role of oncogene in tumor tissues, and promote the development of tumor by affecting the proliferation, migration, invasion and metastasis of tumor cells. Some lnc RNAs has become a diagnostic and prognostic marker of specific tumors. The study of its expression, function and mechanism has become a hot topic in current tumor research, but it is mainly focused on epithelial-derived tumors. The purpose of this article is to review the research progress of lnc RNAs in lymphatic hematopoietic tumors.
【作者单位】： 天津医科大学肿瘤医院病理科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心;
【基金】：国家肿瘤临床医学研究中心个体化医学平台建设项目(编号:13ZCZCSY20300)资助~~
【分类号】：R733
本文编号：2187877
[Abstract]:Long chain noncoding RNAs (long noncoding RN Aslnc RNAs is a nonprotein encoded transcript with a length of more than 200 nucleotides. Most of lnc RNAs show the role of oncogene in tumor tissues, and promote the development of tumor by affecting the proliferation, migration, invasion and metastasis of tumor cells. Some lnc RNAs has become a diagnostic and prognostic marker of specific tumors. The study of its expression, function and mechanism has become a hot topic in current tumor research, but it is mainly focused on epithelial-derived tumors. The purpose of this article is to review the research progress of lnc RNAs in lymphatic hematopoietic tumors.
【作者单位】： 天津医科大学肿瘤医院病理科国家肿瘤临床医学研究中心天津市肿瘤防治重点实验室天津市恶性肿瘤临床医学研究中心;
【基金】：国家肿瘤临床医学研究中心个体化医学平台建设项目(编号:13ZCZCSY20300)资助~~
【分类号】：R733
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