胰高血糖素瘤70例临床荟萃分析

发布时间：2018-08-19 10:20

【摘要】：目的：探讨胰高血糖素瘤的临床特征及诊治方法。方法：收集中国1981—-2012年中文文献报道的101例胰高血糖素瘤病人的临床资料,删除重复报道的31例病例,将剩余可使用的70例临床病例按年龄、性别、临床表现、肿瘤部位及大小、有无转移及转移部位、手术治疗等项目进行分析。结果：男性34例,女性36例,年龄位于28～79岁之间,平均48.8岁。有坏死溶解性游走性红斑、糖尿病、体重减轻、贫血、舌炎／口腔炎／唇炎的病人分别为60例、56例、50例、37例、39例。对肿瘤部位进行详细描述的56例,其中25例肿瘤位于胰腺体尾部,占44.6%。确诊时已有肝转移者34例。行手术治疗者50例(50/70；71.4%)。结论：胰高血糖素瘤是一类具有高转移性的肿瘤,在胰腺内部具有沿胰腺蔓延的趋势,且具有多中心起源的可能性,手术治疗是其最为有效的治疗手段。
[Abstract]:Objective: to investigate the clinical features, diagnosis and treatment of glucagon tumor. Methods: the clinical data of 101 cases of glucagon tumor reported in Chinese literature from 1981 to 2012 were collected, 31 cases of repeated reports were deleted, and the remaining 70 cases were classified according to age, sex and clinical manifestation. Tumor location and size, metastasis and metastasis, surgical treatment and other items were analyzed. Results: there were 34 males and 36 females, aged between 28 and 79 years, with an average age of 48.8 years. The number of patients with necrotic soluble wandering erythema, diabetes, weight loss, anemia, glossitis / stomatitis / lip were 60 / 56 / 50 / 37 / 39 respectively. Of the 56 cases whose tumors were described in detail, 25 cases were located in the caudal part of the pancreas, accounting for 44.6%. There were 34 cases of liver metastasis at the time of diagnosis. Operation was performed in 50 cases (50 / 70 71.4%). Conclusion: glucagon tumor is a kind of tumor with high metastasis. It has the tendency of spreading along the pancreas and has the possibility of multi-center origin. Surgical treatment is the most effective treatment method.
【学位授予单位】：重庆医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R735.9

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