四维CT定位技术在早期肺癌靶区勾画中应用研究

发布时间：2018-08-22 09:07

【摘要】：目的放射治疗是不能耐受或不愿手术的早期肺癌患者的主要治疗手段,精确定位是影响早期肺癌的关键。本研究早期肺癌患者行常规三维CT扫描和四维CT(four-dimensional computed tomography,4D-CT)扫描后,勾画得到各呼吸时相图像和最大密度投影图像的大体肿瘤体积(gross tumor volume,GTV),探讨早期肺癌靶区勾画的最佳途径。方法选取青岛市中心(肿瘤)医院2016-01-01-2016-09-30的10例早期肺癌患者行4D-CT定位,将整个呼吸周期平均分为10个时相,分别为CT0、CT10、......CT90,其中CT0为吸气末,CT50为呼气末。在4D-CT图像的基础上得到最大密度投影图像,并分别在4D-CT不同时相和最大密度投影图像上勾画靶区。以整个呼吸周期10个呼吸时相靶区体积叠加为参考,比较不同状态下得到的GTV体积。结果最大密度投影、两极限时相图像叠加分别与参考GTV体积比值为0.86±0.077和0.848±0.074,靶区中心点位移X为0.105±0.079和0.037±0.031,Y为0.134±0.102和0.104±0.095,Z为0.107±0.107和0.051±0.055。结论最大密度投影和两极限时相图像叠加与参考图像靶区较为相似,可用来帮助勾画靶区。
[Abstract]:Objective radiotherapy is the main treatment method for early lung cancer patients who are intolerant or unwilling to operate, and accurate positioning is the key to affect early lung cancer. In this study, after routine three-dimensional CT and four-dimensional computed tomographic 4D-CT scanning, the gross tumor volume (gross tumor volume of each respiratory phase and maximum density projection images were obtained, and the best way to map the target area of early lung cancer was explored. Methods 4D-CT localization was performed in 10 patients with early lung cancer from 2016-01-2016-09-30 in Qingdao Central (tumor) Hospital. The whole respiratory cycle was divided into 10 phases: CT0 CT10N. CT90, in which CT0 was CT50 at the end of inspiratory breath. On the basis of 4D-CT image, the maximum density projection image is obtained, and the target area is drawn on the different phase and maximum density projection image of 4D-CT, respectively. The volume of GTV obtained in different states was compared with the volume of target area of 10 phases in the whole respiratory cycle. Results the maximum density projection, the ratio of superposition to reference GTV volume were 0.86 卤0.077 and 0.848 卤0.074, respectively, and the center shift X of target area were 0.105 卤0.079 and 0.037 卤0.031 Y, 0.134 卤0.102 and 0.104 卤0.095 卤0.107 卤0.107 and 0.051 卤0.055, respectively. Conclusion the maximum density projection and the bipolar time-limited phase superposition are similar to the reference image targets, which can be used to help to draw the target areas.
【作者单位】：济南大学·山东省医学科学院医学与生命科学学院;青岛市中心(肿瘤)医院放射物理科;山东省医学科学院山东大学附属山东省肿瘤医院放射物理技术科;
【分类号】：R734.2

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