多胎妊娠合并葡萄胎12例临床特征分析
发布时间：2018-08-24 10:47
【摘要】：目的探讨多胎妊娠合并葡萄胎的临床特征。方法收集12例多胎妊娠合并葡萄胎病例资料,分析其临床特征、超声检查结果、妊娠结局等。结果 12例患者中无一例自然妊娠,2例行促排卵治疗后妊娠,其余10例均行体外受精-胚胎移植(IVF-ET)后妊娠。9例为双胎妊娠合并葡萄胎,2例为3胎妊娠合并葡萄胎,1例为4胎妊娠合并葡萄胎。12例患者中,4例出现妊娠剧吐,10例有严重阴道流血,2例出现腹痛,1例并发子痫前期、甲状腺功能亢进症及转氨酶升高,2例并发亚临床甲状腺功能亢进,3例并发甲状腺功能亢进症,6例甲状腺功能正常。1例足月剖宫产活产一男婴,其余11例均终止妊娠。2例于清宫术后血人绒毛膜促性腺激素(h CG)不降反升和持续平台期,疑为持续性滋养细胞疾病,给予单药化疗,最后随访至正常。结论多胎妊娠合并葡萄胎的并发症多见,且有发生持续性滋养细胞疾病的风险。多数患者终止妊娠,当未出现明显孕妇及胎儿并发症及患者有继续妊娠的愿望时可在密切监测继续妊娠。
[Abstract]:Objective to investigate the clinical features of multiple pregnancy with hydatidiform mole. Methods 12 cases of multiple pregnancy complicated with hydatidiform mole were collected and their clinical features, ultrasonic findings and pregnancy outcome were analyzed. Results none of the 12 patients had spontaneous pregnancy and 2 cases had pregnancy after ovulation promotion therapy. The remaining 10 cases were treated with in vitro fertilization and embryo transfer (IVF-ET). 9 cases of pregnancy were twin pregnancy combined with hydatidiform mole. 2 cases were 3 pregnancies with hydatidiform mole. 1 case was 4 cases of pregnancy with hydatidiform mole. 12 cases were pregnant with hyperemesis in 10 cases. Severe vaginal bleeding occurred in 2 cases, abdominal pain occurred in 1 case, and preeclampsia occurred in 1 case. Hyperthyroidism and elevated transaminase in 2 cases with subclinical hyperthyroidism 3 cases with hyperthyroidism 6 cases with normal thyroid function 1 cases with full-term cesarean section gave birth to a male baby. All the other 11 cases terminated pregnancy in 2 cases. The serum human chorionic gonadotropin (h CG) did not decrease and rise in the stage of persistent plateau, suspected as persistent trophoblastic disease, received single drug chemotherapy, and was followed up to normal at last. Conclusion the complications of multiple pregnancy complicated with hydatidiform mole are common and at risk of persistent trophoblastic disease. Most patients terminate pregnancy and continue pregnancy under close monitoring when there are no obvious pregnancy and fetal complications and the patient has the desire to continue pregnancy.
【作者单位】： 中山大学附属第一医院妇产科;中山大学附属第一医院超声科;
【分类号】：R714.2;R737.33
，
本文编号：2200577
[Abstract]:Objective to investigate the clinical features of multiple pregnancy with hydatidiform mole. Methods 12 cases of multiple pregnancy complicated with hydatidiform mole were collected and their clinical features, ultrasonic findings and pregnancy outcome were analyzed. Results none of the 12 patients had spontaneous pregnancy and 2 cases had pregnancy after ovulation promotion therapy. The remaining 10 cases were treated with in vitro fertilization and embryo transfer (IVF-ET). 9 cases of pregnancy were twin pregnancy combined with hydatidiform mole. 2 cases were 3 pregnancies with hydatidiform mole. 1 case was 4 cases of pregnancy with hydatidiform mole. 12 cases were pregnant with hyperemesis in 10 cases. Severe vaginal bleeding occurred in 2 cases, abdominal pain occurred in 1 case, and preeclampsia occurred in 1 case. Hyperthyroidism and elevated transaminase in 2 cases with subclinical hyperthyroidism 3 cases with hyperthyroidism 6 cases with normal thyroid function 1 cases with full-term cesarean section gave birth to a male baby. All the other 11 cases terminated pregnancy in 2 cases. The serum human chorionic gonadotropin (h CG) did not decrease and rise in the stage of persistent plateau, suspected as persistent trophoblastic disease, received single drug chemotherapy, and was followed up to normal at last. Conclusion the complications of multiple pregnancy complicated with hydatidiform mole are common and at risk of persistent trophoblastic disease. Most patients terminate pregnancy and continue pregnancy under close monitoring when there are no obvious pregnancy and fetal complications and the patient has the desire to continue pregnancy.
【作者单位】： 中山大学附属第一医院妇产科;中山大学附属第一医院超声科;
【分类号】：R714.2;R737.33
，
本文编号：2200577
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