BALF中PTX3水平对肺部孤立块影良恶性的鉴别价值

发布时间：2018-08-26 09:07

【摘要】：研究目的:探讨检测支气管肺泡灌洗液(BALF)中正五聚素(PTX3)水平对肺部孤立块影良恶性的鉴别价值。研究方法:选取本院因胸部CT检查发现肺部孤立块影行支气管镜检查的患者87例,其中肺癌组53例,肺良性病变组34例,采用酶联免疫吸附试验(ELISA)检测支气管肺泡灌洗液中正五聚素(PTX3)水平。研究结果:(1)BALF中PTX3的水平肺癌组高于肺部良性病变组,差异有统计学意义(4.0±0.4ng/ml vs 2.7±0.5ng/ml,P=0.0274)。(2)BALF中PTX3的水平鳞癌亚组高于肺部良性病变组,差异有显著统计学意义(4.5±0.4ng/ml vs 2.7±0.5ng/ml,P=0.0062)。(3)BALF中PTX3水平腺癌亚组、小细胞癌亚组与肺部良性病变组之间,差异无统计学意义(3.4±0.6ng/ml vs 2.7±0.5ng/ml,P=0.4332;1.9±0.7ng/ml vs2.7±0.5ng/ml,P=0.4964)。(4)BALF PTX3诊断肺癌的最佳截断值为:0.2623ng/ml,其诊断肺癌的敏感度为60.38%,特异度为55.88%。(5)BALF PTX3诊断肺鳞癌的最佳截断值为:2.195ng/ml,其诊断肺鳞癌的敏感度为80.00%,特异度为67.65%。结论:用酶联免疫吸附试验(ELISA)检测BALF中PTX3水平可作为鉴别肺部孤立块影良恶性的辅助指标之一,对区分鳞癌、腺癌、小细胞癌,提高肺癌的检出率有一定意义,可能具有一定的临床应用价值。
[Abstract]:Objective: to investigate the value of detecting the level of normal pentagglutinin (PTX3) in bronchoalveolar lavage fluid (BALF) for the differential diagnosis of benign and malignant solitary pulmonary masses. Methods: a total of 87 patients, including 53 patients with lung cancer and 34 patients with benign pulmonary lesions, were selected for bronchoscopy in our hospital. The level of normal pentagglutinin (PTX3) in bronchoalveolar lavage fluid (BALF) was detected by enzyme linked immunosorbent assay (ELISA). Results: (1) the level of PTX3 in BALF was significantly higher in lung cancer group than in benign lung disease group (4.0 卤0.4ng/ml vs 2.7 卤0.5ng / ml P0.0274). (2). The level of PTX3 in BALF was significantly higher than that in benign lung disease group (4.5 卤0.4ng/ml vs 2.7 卤0.5ng / ml P 0.0062). (3), and the difference was statistically significant (4.5 卤0.4ng/ml vs 2.7 卤0.5ng / ml P 0.0062). (3). Between the small cell carcinoma subgroup and the benign lung disease group, There was no significant difference (3.4 卤0.6ng/ml vs 2.7 卤0.5ng / ml P0.4332and 1.9 卤0.7ng/ml vs2.7 卤0.5ngml / ml 0.4964). (4) in the diagnosis of lung cancer. The best truncation value of BALF PTX3 in the diagnosis of lung cancer was: 0.2623ng / ml. The sensitivity and specificity of BALF PTX3 were 60.38 and 55.881.The best truncation value of BALF PTX3 in the diagnosis of squamous cell carcinoma was 2.195 ng / ml, the sensitivity was 87.65 ng / ml and the specificity was 67.65 ng / ml. Conclusion: the detection of PTX3 level in BALF by enzyme linked immunosorbent assay (Elisa) can be used as one of the auxiliary indexes in differentiating benign and malignant solitary masses of lung, and it is of significance in differentiating squamous cell carcinoma, adenocarcinoma, small cell carcinoma and increasing the detection rate of lung cancer. May have certain clinical application value.
【学位授予单位】：宁波大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R734.2

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