恶性肿瘤PICC患者血清CRP及PCT和SAA的水平与感染关系研究

发布时间：2018-08-28 18:40

【摘要】：目的探讨恶性肿瘤经外周静脉置入中心静脉导管(PICC)患者血清C-反应蛋白(CRP)、降钙素原(PCT)及淀粉样蛋白(SAA)水平与感染之间的相互关系。方法选取2013年1月-2015年12月在医院行PICC的458例恶性肿瘤患者为临床研究对象,并比较和分析感染与非感染患者、不同感染类型患者及不同感染部位患者血清CRP、PCT及SAA水平的变化情况。结果 458例恶性肿瘤PICC患者中发生感染74例,感染率为16.16%;细菌感染56例,占75.68%;病毒感染18例,占24.32%;血行感染16例,占21.62%;局部感染58例,占78.38%;与非感染患者相比,恶性肿瘤PICC感染患者血清CRP(70.56±8.92)mg/L、PCT(3.61±0.45)ng/ml、SAA(246.78±21.36)mg/L水平均明显升高,差异均具有统计学意义(P0.05);与病毒感染患者相比,恶性肿瘤PICC细菌感染患者血清CRP(103.35±12.41)mg/L、PCT(6.59±0.64)ng/ml、SAA(359.20±40.53)mg/L水平均明显升高,差异均有统计学意义(P0.05);与局部感染患者相比,恶性肿瘤PICC血行感染患者血清CRP(115.40±10.27)mg/L、PCT(7.62±0.48)ng/ml、SAA(383.71±42.50)mg/L水平均明显升高,差异均有统计学意义(P0.05)。结论血清CRP、PCT、SAA水平与恶性肿瘤PICC感染之间具有密切的相关性,对于恶性肿瘤PICC感染的诊断和鉴别具有十分重要的临床参考价值。
[Abstract]:Objective to investigate the relationship between serum levels of C- reactive protein (CRP), procalcitonin (PCT) and amyloid (SAA) and infection in patients with malignant tumor treated with central venous catheter (PICC) via peripheral vein. Methods 458 patients with PICC from January 2013 to December 2015 were selected as the clinical study subjects, and the infected and non-infected patients were compared and analyzed. Changes of serum CRP,PCT and SAA levels in patients with different infection types and different infection sites. Results there were 74 cases of infection in 458 patients with malignant tumor PICC, 56 cases of bacterial infection (75.68%), 18 cases of viral infection (24.32 2%), 16 cases of hematologic infection (21.622%), 58 cases of local infection (78.38%), and 58 cases of local infection (78.38%). The levels of serum CRP (70.56 卤8.92) mg/L,PCT (3.61 卤0.45) ng/ml,SAA (246.78 卤21.36) mg/L in patients with PICC infection were significantly higher than those in patients with viral infection (P0.05), and the levels of CRP (103.35 卤12.41) mg/L,PCT (6.59 卤0.64) ng/ml,SAA (359.20 卤40.53) mg/L in patients with bacterial infection of PICC were significantly higher than those in patients with viral infection. The serum CRP (115.40 卤10.27) mg/L,PCT (7.62 卤0.48) ng/ml,SAA (383.71 卤42.50) mg/L levels of patients with malignant tumor PICC were significantly higher than that of local infection patients (P0.05). Conclusion there is a close correlation between serum CRP,PCT,SAA level and PICC infection in malignant tumors, which is very important for the diagnosis and differential diagnosis of PICC infection in malignant tumors.
【作者单位】：安阳市人民医院全科医学科;安阳市人民医院血液内科;安阳市人民医院急救中心;安阳市人民医院检验科;安阳市人民医院院感疾病科;安阳市人民医院营养科;
【基金】：河南省卫计委基金资助项目(20120017)
【分类号】：R730.43

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