初诊时的严格分期对滤泡细胞淋巴瘤患者预后的影响
发布时间：2018-08-31 10:38
【摘要】：背景:既往研究表明,在早期滤泡细胞淋巴瘤(FL)患者中初诊时接受严格分期的患者,其预后明显优于非严格分期的患者,在国内尚未见相关报道。目的:探讨初诊时严格分期与各期FL患者预后之间的关系。方法:收集和分析2008年到2014年共111名初诊FL患者的临床资料,其中Ⅰ-Ⅱ期患者42名,Ⅲ-Ⅳ期患者69名。严格分期定义为必须满足以下2个必要条件:①骨髓穿刺和骨髓活检;②全身影像学检查(涵盖全身的CT和超声、PET/CT,至少满足1项)。检查不满足任1项即视为非严格的分期。结果:对早期的FL患者,接受严格分期患者的PFS明显优于未经严格分期者(P=0.048)。针对各期FL患者的单因素分析显示,年龄60岁、LDH升高、骨髓受累、大于3 cm病灶多于3处者,均与不良预后相关。多因素分析表明,年龄、LDH水平、骨髓受累为独立预后因素。结论:对于初治的早期FL患者,接受严格分期者较未接受严格分期者有更好的预后。骨髓是否受累与预后密切相关,临床工作中应重视骨髓状况的评价。
[Abstract]:Background: previous studies have shown that the prognosis of patients with early follicular cell lymphoma (FL) receiving strict staging is significantly better than that of patients with non-strict staging. No related reports have been reported in China. Objective: to investigate the relationship between strict staging and prognosis of patients with FL. Methods: the clinical data of 111 newly diagnosed FL patients from 2008 to 2014 were collected and analyzed, including 42 patients with stage 鈪，
本文编号：2214730
[Abstract]:Background: previous studies have shown that the prognosis of patients with early follicular cell lymphoma (FL) receiving strict staging is significantly better than that of patients with non-strict staging. No related reports have been reported in China. Objective: to investigate the relationship between strict staging and prognosis of patients with FL. Methods: the clinical data of 111 newly diagnosed FL patients from 2008 to 2014 were collected and analyzed, including 42 patients with stage 鈪，
本文编号：2214730
本文链接：https://www.wllwen.com/yixuelunwen/zlx/2214730.html
