乳腺癌中p53与雌激素受体相互作用影响的研究进展及意义
发布时间：2018-09-01 09:15
【摘要】：在女性的恶性肿瘤发病率中,乳腺癌排名第一,对女性的生命和健康造成了严重威胁。乳腺癌的治疗包括手术治疗、化疗、放疗、内分泌治疗及分子靶向治疗。随着对乳腺癌治疗的不断深入,多靶点治疗的联合应用成为研究热点。野生型p53基因是一种抑癌基因,其基因突变是乳腺癌形成的重要因素。导入正常的p53可以恢复p53的正常功能。重组p53腺病毒(adenovirus mediated p53 gene,Ad-p53)是将野生型p53基因导入腺病毒,通过其转导将正常p53导入p53基因突变的乳腺癌细胞中,导入的p53合成p53蛋白,恢复p53正常的抑癌功能。雌激素受体(estrogen receptor,ER)对于乳腺癌的治疗具有重要作用。乳腺癌内分泌治疗出发点是抑制ER发挥传导信号或者降低ER数量。根据最新研究,p53和ER的表达相互调节,p53可促进ER的表达;ER可抑制p53的功能。本文阐述p53、ER对乳腺癌作用机制及相互作用进展进行分析总结,综述有利于推动乳腺癌p53、ER双靶点治疗。
[Abstract]:Breast cancer ranks first in the incidence of malignant tumors in women, posing a serious threat to women's lives and health. Breast cancer treatment includes surgical treatment, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy. With the development of breast cancer therapy, the combined application of multi-target therapy has become a hot topic. Wild type p53 gene is a tumor suppressor gene and its mutation is an important factor in the formation of breast cancer. The normal function of p53 can be restored by the introduction of normal p53. Recombinant p53 adenovirus (adenovirus mediated p53 gene,Ad-p53) is a wild type p53 gene transfected into breast cancer cells with normal p53 gene mutation through its transduction. P53 synthesizes p53 protein and recovers normal tumor suppressor function of p53. Estrogen receptor (estrogen receptor,ER) plays an important role in the treatment of breast cancer. The starting point of endocrine therapy for breast cancer is to inhibit ER signaling or reduce the number of ER. According to the latest research, the expression of p53 and ER can regulate each other. P53 can promote the expression of ER. ER can inhibit the function of p53. In this paper, the mechanism and interaction progress of p53ER in breast cancer were analyzed and summarized, which was helpful to promote the treatment of breast cancer with double target p53ER.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9
本文编号：2216741
[Abstract]:Breast cancer ranks first in the incidence of malignant tumors in women, posing a serious threat to women's lives and health. Breast cancer treatment includes surgical treatment, chemotherapy, radiotherapy, endocrine therapy and molecular targeted therapy. With the development of breast cancer therapy, the combined application of multi-target therapy has become a hot topic. Wild type p53 gene is a tumor suppressor gene and its mutation is an important factor in the formation of breast cancer. The normal function of p53 can be restored by the introduction of normal p53. Recombinant p53 adenovirus (adenovirus mediated p53 gene,Ad-p53) is a wild type p53 gene transfected into breast cancer cells with normal p53 gene mutation through its transduction. P53 synthesizes p53 protein and recovers normal tumor suppressor function of p53. Estrogen receptor (estrogen receptor,ER) plays an important role in the treatment of breast cancer. The starting point of endocrine therapy for breast cancer is to inhibit ER signaling or reduce the number of ER. According to the latest research, the expression of p53 and ER can regulate each other. P53 can promote the expression of ER. ER can inhibit the function of p53. In this paper, the mechanism and interaction progress of p53ER in breast cancer were analyzed and summarized, which was helpful to promote the treatment of breast cancer with double target p53ER.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R737.9
【参考文献】
相关期刊论文 前10条
1 王静;宋瑾;卫刚;任扩军;戚晓东;;重组人p53腺病毒诱导乳腺癌细胞MCF-7凋亡的作用[J];中国医刊;2014年04期
2 蔡绍海;戚晓东;宋瑾;王静;;Ad-p53对乳腺癌细胞雌激素受体表达的影响[J];中国现代普通外科进展;2013年09期
3 刘睿;赵静;张志;曹晓艳;杨照环;;雌激素受体亚型ERα、ERβ在乳腺癌中的表达及意义[J];中国实验诊断学;2012年06期
4 刘英华;何宁;姜淑卿;李新;张静姝;;雌激素及雌激素受体拮抗剂对人乳腺癌细胞MCF-7中雌激素相关受体表达的影响[J];环境与健康杂志;2011年08期
5 陈磊;石林祥;郑莉莉;卢少毅;徐蕾;;CerbB-2、P53、ER、PR在乳腺癌中的表达及临床意义[J];同济大学学报(医学版);2008年03期
6 成秀梅;;肿瘤抑制基因p53的研究进展[J];现代诊断与治疗;2008年03期
7 何时知;戚晓东;张晓明;王宇;;腺病毒介导p53基因逆转乳腺癌耐药的实验研究[J];中华医学杂志;2007年41期
8 董桂兰;张小楠;袁文棋;;EZH2和p53在乳腺癌中的表达及相关性探讨[J];中国肿瘤临床;2007年16期
9 杨蕾;秦占芬;蒋湘宁;徐晓白;;雌激素致乳腺癌机制的研究进展[J];肿瘤防治研究;2006年11期
10 刘进,薛新波;P53、VEGF和VEGF-C在胰腺癌中的表达及意义[J];华中科技大学学报(医学版);2004年04期
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