OCT4表达与非小细胞肺癌临床病理特征关系的Meta分析

发布时间：2018-09-01 09:51

【摘要】：目的:旨在使用Meta分析方法系统评价八聚体结合转录因子4(octamer-binding transcription factor 4,OCT4)表达与非小细胞肺癌(non-small cell lung cancer,NSCLC)临床病理特征的关系。方法:电子检索Pub Med、Embase、中国生物医学文献数据库、中国学术期刊全文数据库、维普中文科技核心全文数据库以及万方数据库,检索时间从建库至2016年3月,查找涉及OCT4表达与NSCLC临床病理特征相关的病例对照研究。参照Cochrane协作网推荐的方法进行筛选及提取数据并评价纳入研究的质量,运用Revman 5.2软件及Stata 12.0软件进行Meta分析。结果:共纳入10个研究,905例患者。OCT4阳性组471例,OCT4阴性组434例。Meta分析结果显示,OCT4阳性表达与肺腺癌(OR=1.75,95%CI=1.22~2.53,P=0.003)、低分化癌(OR=2.93,95%CI=1.25~6.84,P=0.010)、中分化癌(OR=1.81,95%CI=1.12~2.94,P=0.020)、T3/T4期肿瘤(OR=1.95,95%CI=1.10~3.45,P=0.020)、术后生存期短(鳞癌:MD=-4.49,95%CI=-7.73~-1.55,P=0.003;腺癌:MD=-8.52,95%CI=-9.82~-7.23,P=0.000)及总体生存率低下(HR=1.99,95%CI=1.52~2.60)关系较为密切,差异均具有统计学意义。结论:OCT4阳性表达与肺腺癌、NSCLC恶性特征以及预后不良密切相关,可以为肺癌靶向治疗提供可靠的科学依据。
[Abstract]:Objective: to evaluate the relationship between the expression of octamer binding transcription factor 4 (octamer-binding transcription factor 4) and clinicopathological features of non-small cell lung cancer (non-small cell lung cancer,NSCLC) by Meta assay. Methods: Pub Med,Embase, Chinese biomedical literature database, Chinese academic journal full-text database, Weipu Chinese science and technology core full-text database and Wanfang database were searched electronically. The retrieval time was from the establishment of the database to March 2016. A case-control study involving the expression of OCT4 and the clinicopathological features of NSCLC was found. According to the method recommended by Cochrane Cooperative Network, the data were screened and extracted, and the quality of the study was evaluated. The Meta analysis was carried out with Revman 5.2 software and Stata 12.0 software. 缁撴灉:鍏辩撼鍏，

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