外周血淋巴细胞和单核细胞计数及其比值对初治多发性骨髓瘤患者预后的预测价值
发布时间：2018-09-04 06:07
【摘要】：目的:探讨外周血淋巴细胞绝对计数(absolute lymphocyte count,ALC)、单核细胞绝对计数(absolute monocyte count,AMC)和ALC/AMC比值(ALC/AMC ratio,LMR)在初治多发性骨髓瘤(multipe myeloma,MM)患者预后中的预测价值。方法:回顾性分析天津医科大学肿瘤医院2005年1月—2015年12月收治的190例初治MM患者,分析外周血ALC、AMC和LMR与外周血血红蛋白(hemoglobin,Hb)、β_2-微球蛋白(β_2-microglobulin,β_2-MG)和乳酸脱氢酶(lactic dehydrogenase,LDH)以及骨髓浆细胞比例等临床指标之间的关系。通过受试者操作特征(receiver operating characteristic,ROC)曲线确定初治MM患者的ALC、AMC和LMR的界值。生存分析采用Kaplan-Meier法,log-rank检验进行预后的单因素分析,COX比例风险模型进行预后的多因素分析。结果:通过ROC曲线确定ALC、AMC和LMR的界值分别为1.24×10~9/L、0.60×10~9/L和3.90,并以此为标准将患者分入高值组和低值组。多因素分析结果显示,ALC1.24×10~9/L[风险比:0.544(95%可信区间:0.301~0.984),P=0.044)、LMR≤3.90[风险比:2.284(95%可信区间:1.018~5.124),P=0.045]和LDH247 U/L[风险比:1.972(95%可信区间:1.087~3.576),P=0.025]是初治MM患者独立的预后不良因素。按每一例患者预后不良因素的数目(每一项独立的预后不良因素记为1分),将患者分入0、1~2和3分组;3组患者的总生存和无进展生存差异均有统计学意义(P值均0.05)。结论:在初治MM患者中,外周血ALC和LMR值越低,提示患者的预后越差。外周血ALC值1.24×10~9/L和LMR≤3.90可能是初治MM患者独立的不良预后因素。
[Abstract]:Objective: to investigate the prognostic value of absolute lymphocyte count (absolute lymphocyte count,ALC), monocyte absolute count (absolute monocyte count,AMC) and ALC/AMC ratio (ALC/AMC ratio,LMR) in patients with newly diagnosed multiple myeloma (multipe myeloma,MM). Methods: a retrospective analysis of 190 patients with primary MM admitted from January 2005 to December 2015 in Cancer Hospital of Tianjin Medical University was performed. The relationship between peripheral blood ALC,AMC and LMR, peripheral blood hemoglobin (hemoglobin,Hb), 尾 _ 2-microglobulin (尾 _ 2-MG), lactate dehydrogenase (lactic dehydrogenase,LDH) and ratio of bone marrow plasmacytes was analyzed. The threshold values of ALC,AMC and LMR in newly treated MM patients were determined by the (receiver operating characteristic,ROC curve. Survival analysis was performed with Kaplan-Meier 's log-rank test for univariate analysis of prognosis and Cox proportional risk model for multivariate analysis of prognosis. Results: ALC,AMC and LMR were determined as 1.24 脳 10 ~ (9) / L 0.60 脳 10 ~ (9) / L and 3.90 by ROC curve, respectively. The patients were divided into high value group and low value group. Multivariate analysis showed that ALC 1.24 脳 10 9 / L [risk ratio: 0. 544 (95% confidence interval: 0. 301 / 0. 84)] LMR 鈮，
本文编号：2221239
[Abstract]:Objective: to investigate the prognostic value of absolute lymphocyte count (absolute lymphocyte count,ALC), monocyte absolute count (absolute monocyte count,AMC) and ALC/AMC ratio (ALC/AMC ratio,LMR) in patients with newly diagnosed multiple myeloma (multipe myeloma,MM). Methods: a retrospective analysis of 190 patients with primary MM admitted from January 2005 to December 2015 in Cancer Hospital of Tianjin Medical University was performed. The relationship between peripheral blood ALC,AMC and LMR, peripheral blood hemoglobin (hemoglobin,Hb), 尾 _ 2-microglobulin (尾 _ 2-MG), lactate dehydrogenase (lactic dehydrogenase,LDH) and ratio of bone marrow plasmacytes was analyzed. The threshold values of ALC,AMC and LMR in newly treated MM patients were determined by the (receiver operating characteristic,ROC curve. Survival analysis was performed with Kaplan-Meier 's log-rank test for univariate analysis of prognosis and Cox proportional risk model for multivariate analysis of prognosis. Results: ALC,AMC and LMR were determined as 1.24 脳 10 ~ (9) / L 0.60 脳 10 ~ (9) / L and 3.90 by ROC curve, respectively. The patients were divided into high value group and low value group. Multivariate analysis showed that ALC 1.24 脳 10 9 / L [risk ratio: 0. 544 (95% confidence interval: 0. 301 / 0. 84)] LMR 鈮，
本文编号：2221239
本文链接：https://www.wllwen.com/yixuelunwen/zlx/2221239.html
