年轻乳腺癌患者保乳手术治疗局部复发的影响因素研究

发布时间：2018-09-06 13:39

【摘要】：目的分析年轻乳腺癌患者保乳治疗(BCT)后局部复发的影响因素。方法收集2005年1月至2010年1月于该院行BCT的患者360例,进行回顾性分析。收集患者临床和病理资料,包括肿瘤大小、淋巴结状态、肿瘤TNM分期、病理类型、切缘状态、人表皮生长因子受体2(Her-2)、雌激素受体(ER)/孕激素受体(PR)和Ki-67。采用单因素分析及Logistic回归分析进行独立危险因素分析。结果患者行BCT后局部复发率为10.56%。单因素分析显示,肿瘤大小、TNM分期、病理分型和ER/PR比值均对年轻患者BCT后局部复发无影响(P0.05);淋巴结转移、切缘状态、Her-2和Ki-67均可影响年轻患者BCT后的局部复发率(P0.05)。Logistic回归分析显示,淋巴结状态、Her-2和切缘状态为年轻患者BCT后局部复发的独立危险因素(P0.05)。结论淋巴转移、Her-2阳性和切缘状态是年轻乳腺癌患者行BCT后局部复发的影响因素。
[Abstract]:Objective to analyze the influencing factors of local recurrence after breast conserving therapy in young breast cancer patients with (BCT). Methods from January 2005 to January 2010, 360 patients with BCT were retrospectively analyzed. Collect clinical and pathological data of patients, including tumor size, lymph node status, tumor TNM staging, pathological type, margin status, human epidermal growth factor receptor 2 (Her-2), estrogen receptor (ER) / progesterone receptor (PR) and Ki-67. The independent risk factors were analyzed by single factor analysis and Logistic regression analysis. Results the local recurrence rate was 10.56% after BCT. Univariate analysis showed that tumor size and TNM staging, pathological classification and ER/PR ratio had no effect on local recurrence after BCT in young patients (P0.05), lymph node metastasis, margin Her-2 and Ki-67 could all affect the local recurrence rate of BCT in young patients (P0.05). Lymph node status Her-2 and margin state were independent risk factors for local recurrence after BCT in young patients (P0.05). Conclusion the positive rate of Her-2 and the margin of lymphatic metastasis are the influential factors for local recurrence after BCT in young breast cancer patients.
【作者单位】：常州市第一人民医院乳腺科;
【分类号】：R737.9

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