寡转移性前列腺癌根治术的临床初步疗效观察及围手术期并发症分析

发布时间：2018-09-08 11:11

【摘要】：背景与目的:多项回顾性研究显示,寡转移性前列腺癌根治术可以提高肿瘤的局部控制率和患者的总生存受益,围手术期并发症是影响寡转移性前列腺癌患者行前列腺癌根治术的一个重要因素。该研究旨在探讨寡转移性前列腺癌患者行前列腺癌根治术的临床初步疗效及围手术期并发症发生率和严重程度。方法:收集2015年7月—2016年1月247例前列腺癌根治术患者数据,其中寡转移性前列腺癌患者25例,局限性前列腺癌患者222例。两组均采用Clavien-Dindo手术并发症分级标准对出现并发症的患者进行分级。观察前列腺特异性抗原(prostate specific antigen,PSA)下降比例并将并发症发生率与严重程度在寡转移组和非寡转移组间进行对比分析。结果:寡转移组术后3个月时21例(84.0%)出现下降PSA,下降比例低于局限组212例(95.5%),差异有统计学意义(P0.05)。寡转移组共6例(24.0%)患者发生术后并发症,其中严重并发症(Ⅲ度及以上)1例(4.0%),局限组共49例(22.1%)患者发生术后并发症,其中严重并发症(Ⅲ度及以上)7例(3.2%),差异无统计学意义(P0.05)。结论:寡转移性前列腺癌患者行前列腺癌根治术治疗是安全、有效和可行的,并发症风险并非寡转移性前列腺癌患者行前列腺癌根治术的限制因素。
[Abstract]:BACKGROUND AND OBJECTIVE: Retrospective studies have shown that radical prostatectomy for oligometastatic prostate cancer can improve local tumor control and overall survival benefit. Perioperative complications are an important factor affecting radical prostatectomy for oligometastatic prostate cancer. Methods: Data of 247 patients with radical prostatectomy from July 2015 to January 2016 were collected, including 25 patients with oligometastatic prostate cancer and 222 patients with localized prostate cancer. The incidence and severity of complications were compared between oligometastasis group and non-oligometastasis group. Results: At 3 months after operation, 21 patients (84.0%) in oligometastasis group showed a decrease in PSA, which was lower than that in the control group. There were 212 cases (95.5%) in the limited group, and the difference was statistically significant (P 0.05). Six cases (24.0%) in the oligometastasis group had postoperative complications, including 1 case (4.0%) of severe complications (grade III and above), and 49 cases (22.1%) in the limited group had postoperative complications, including 7 cases (3.2%) of severe complications (grade III and above), with no significant difference (P 0.05). Radical prostatectomy is safe, effective and feasible for patients with metastatic prostate cancer, and the risk of complications is not a limiting factor for patients with oligometastatic prostate cancer undergoing radical prostatectomy.
【作者单位】：复旦大学附属肿瘤医院泌尿外科复旦大学上海医学院肿瘤学系;复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系;
【分类号】：R737.25

【相似文献】