三切口食管癌根治术后患者医院感染病原菌分布与耐药性分析

发布时间：2018-09-12 11:23

【摘要】：目的调查三切口食管癌根治术后患者发生医院感染时病原菌分布特点以及常见抗菌药物的耐药性,为临床合理选择抗菌药物提供依据。方法回顾性调查2014年7月-2016年10月在医院施行三切口食管癌根治术428例患者的临床资料,分析术后感染率,检测感染病原菌分布及耐药性结果;采用SPSS 22.0软件对数据进行分析。结果术后发生医院感染72例,感染率为16.82%;共检出201株病原菌,以革兰阴性菌为主,共95株占47.26%,其次为革兰阳性菌,共77株占38.31%,真菌29株,占14.43%;革兰阴性菌对哌拉西林/他唑巴坦敏感率较高,均30.00%。结论三切口术后患者发生院内感染后,病原菌分布以革兰阴性菌为主,而革兰阳性菌所占比重较大,依据常见药物的耐药性,推荐使用较为敏感的哌拉西林/他唑巴坦联合利奈唑胺进行经验性治疗。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria and drug resistance of common antimicrobial agents in patients with hospital infection after radical resection of esophageal cancer through three incisions, so as to provide evidence for rational selection of antibiotics in clinic. Methods the clinical data of 428 patients undergoing triple incision radical resection of esophageal cancer from July 2014 to October 2016 were retrospectively investigated. The infection rate, the distribution of infected pathogens and the results of drug resistance were analyzed by SPSS 22.0 software. Results there were 72 cases of nosocomial infection, the infection rate was 16.82%, 201 strains of pathogenic bacteria were detected, 95 strains were Gram-negative bacteria (47.26%), the next were Gram-positive bacteria, 77 strains were 38.31 strains, and 29 strains were fungi. The sensitivity of Gram-negative bacteria to piperacillin / tazobactam was higher than that to piperacillin / tazobactam. Conclusion after nosocomial infection, the main pathogens were Gram-negative bacteria, and Gram-positive bacteria accounted for a large proportion, according to the drug resistance of common drugs. More sensitive piperacillin / tazobactam combined with Liniazolamine is recommended for empirical treatment.
【作者单位】：中山大学肿瘤防治中心医院感染管理科;中山医学院临床医学系;
【基金】：国家卫生计生委专项基金资助项目(1311200006402)
【分类号】：R735.1;R197.323

【相似文献】