益气升降汤对大肠癌术后患者化疗期间排便习惯改变影响的临床研究

发布时间：2018-09-14 18:27

【摘要】：目的:将《排便习惯改变脾气虚证症状分级量化表》用作参照,对益气升降汤方治疗大肠癌术后患者化疗期间出现排便习惯改变的效应作出评价,同时观察、监测并记录患者治疗的细胞免疫功能、KPS评分、肿瘤标记物水平、肿瘤复发转移情况及化疗时发生的毒副反应,并进行前后对比和分析,由此为益气升降汤治疗大肠癌术后排便异常在临床上推行及广泛应用,为研发新的抗癌中药制剂提供理论依据与新的契机。方法:针对收集的已确诊大肠癌术后患者(60例)展开随机对照临床试验研究,按乱数表法将其分为治疗组和对照组(各30例)。其中接受益气升降汤方联合FOLFOX4方案化疗者为治疗组,单纯接受FOLFOX4方案化疗者为对照组,14天为1周期,连续观察4周期。把《排便习惯改变脾气虚证症状分级量化表》作为益气升降汤所产生治疗效应的主要评定标准,并观察比较常用的疗效性及安全性检测指标在治疗前后的变化。结果:使用益气升降汤中药联合FOLFOX方案化疗的患者在大便次数、频繁便意感/肛门下坠/不尽/胀感方面的前后评分差异有高度统计学意义(P0.01),在粪便性状,排便时间、排便困难/过度用力排便、肠鸣亢进的方面的前后评分差异有统计学意义(P0.05);该组经治疗后在粪便性状、排便困难/过度用力排便、频繁便意感/肛门下坠/不尽/胀感、体倦乏力、恶心呕吐方面与单用FOLFOX方案化疗的评分差异有统计学意义(P0.05);此外结果提示,经秩和检验,该组治疗方法对增加患者细胞免疫功能及体力状况,降低肿瘤指标及化疗毒副作用发生率方面的优势强于对照组,差异有统计学意义(P0.05)。结论:益气升降汤方在化疗期间治疗大肠癌术后患者的排便习惯改变,能够减轻临床症状,调节细胞免疫功能,改善体力状况,在一定程度上能够降低肿瘤标记物值,同时化疗毒副作用轻,值得临床运用。
[Abstract]:Objective:To evaluate the effect of Yiqi Shengjiang Decoction on the change of defecation habits in patients with colorectal cancer after chemotherapy, and to monitor and record the cellular immune function, KPS score, tumor marker level, tumor recurrence and metastasis. The toxicity and side effects of chemotherapy were compared and analyzed before and after treatment, which provided a theoretical basis and a new opportunity for the clinical application of Yiqi Shengjiang Decoction in the treatment of abnormal bowel movements after colorectal cancer surgery, and for the development of New Anticancer Traditional Chinese medicine preparations. The treatment group was treated with Yiqi Shengjiang Decoction combined with FOLFOX4 regimen chemotherapy, and the control group was treated with FOLFOX4 regimen chemotherapy alone. The patients received FOLFOX4 regimen chemotherapy for a period of 14 days for four consecutive cycles of observation. In order to evaluate the therapeutic effect of Yiqi Shengjiang Decoction and observe the changes of the commonly used efficacy and safety indexes before and after treatment.Results:There were significant differences in the scores of fecal frequency, frequent fecal feeling/anal falling/unexhausted/distension between the patients treated with Yiqi Shengjiang Decoction and FOLFOX regimen chemotherapy. Highly statistically significant (P 0.01), there were significant differences in stool traits, defecation time, dyspepsia / overexertion defecation, hypersonic bowel sounds (P 0.05); the group after treatment in the stool traits, dyspepsia / overexertion defecation, frequent fecal sense / anal drop / endless / distension, fatigue, nausea and vomiting There was significant difference between FOLFOX regimen and FOLFOX regimen alone (P 0.05). In addition, the results showed that the treatment group had more advantages than the control group in increasing cellular immune function and physical status, reducing tumor indicators and the incidence of side effects of chemotherapy, and the difference was statistically significant (P 0.05). Jiangtang Decoction can alleviate clinical symptoms, regulate cellular immune function, improve physical condition, to a certain extent, reduce the value of tumor markers, while the side effects of chemotherapy are mild, which is worthy of clinical application.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R735.34

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