三叶因子家族1和细胞周期蛋白D1在胃癌组织中的表达及意义

发布时间：2018-10-08 11:55

【摘要】：目的探讨三叶因子家族(TFF)1和细胞周期蛋白(Cyclin)D1在胃癌组织中的表达及意义。方法收集胃癌标本72例,采用免疫组化SABC染色方法,观察癌旁胃黏膜及胃癌组织中的TFF1和Cyclin D1的表达,分析两者与临床病理参数之间的关系及两者的相关性。结果TFF1在癌旁黏膜及胃癌组织中阳性表达率分别为100.0%和63.3%,Cyclin D1分别为69.8%和41.7%,两者差异显著(P0.01,P0.05);TFF1和Cyclin D1在有淋巴结转移组分别为76.3%及55.6%,无转移组分别为40.9%和18.5%,两者差异显著(P0.01);TFF1的表达与胃癌的分化程度无关,而Cyclin D1在低分化和高中分化腺癌中的表达分别为53.5%和24.1%,两者有统计学差异(P0.05);TFF1在细胞质中表达阳性的同时在细胞核中也有表达,其阳性率与肿瘤细胞的分化程度、浸润深度及淋巴结转移有关。TFF1和Cyclin D1在胃癌中表达呈正相关。结论 TFF1和Cyclin D1表达下调可能在胃癌发生过程中起作用,TFF1在胃癌的不同时期、不同阶段可能起不同作用,TFF1和Cyclin D1的低表达可作为胃癌的预后指标。
[Abstract]:Objective to investigate the expression and significance of trefoil factor family (TFF) 1 and cyclin (Cyclin) D1 in gastric carcinoma. Methods the expression of TFF1 and Cyclin D1 in adjacent gastric mucosa and gastric cancer tissues were observed by immunohistochemical SABC staining in 72 cases of gastric cancer. The relationship between the expression of TFF1 and clinicopathologic parameters and the correlation between them were analyzed. Results the positive expression rates of TFF1 in adjacent mucosa and gastric cancer were 100.0% and 63.3%, respectively. The positive rates of Cyclin D1 were 69.8% and 41.7%, respectively. There was a significant difference between them (P0.01P 0.05). The positive rates of TFF1 in lymph node metastasis group were 76.3% and 55.6%, and those in non-metastasis group were 40.9% and 18.5B, respectively. The expression of TFF1 was not related to the differentiation of gastric cancer. However, the expression of Cyclin D1 was 53.5% and 24.1% in poorly differentiated and well-differentiated adenocarcinoma, respectively. There was significant difference between them (P0.05). The positive rate of Cyclin D1 in cytoplasm was also expressed in the nucleus, and the positive rate was associated with the degree of differentiation of tumor cells. The expression of. TFF1 and Cyclin D1 in gastric cancer was positively correlated with the depth of invasion and lymph node metastasis. Conclusion the down-regulation of TFF1 and Cyclin D1 expression may play an important role in the development of gastric cancer. The low expression of TFF1 and Cyclin D1 may be a prognostic index of gastric cancer.
【作者单位】：延边肿瘤医院病理科;延边大学附属医院病理科;
【基金】：吉林省教育厅项目[吉教科合字2012第6号]
【分类号】：R735.2

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