垂体生长激素腺瘤经蝶手术预后的相关因素分析
发布时间：2018-10-17 07:34
【摘要】：目的:研究垂体生长激素腺瘤术后缓解与哪些因素有关;探究影响和预测垂体生长激素腺瘤术后缓解的相关因素。方法:本研究回顾性分析2009年2月至2014年12月间在本中心接受同一手术小组实施经蝶垂体生长激素腺瘤切除术的患者。根据术后缓解情况分为两组,分别比较两组间不同因素是否存在差异,应用生存分析方法绘制生存曲线,判断其是否影响术后缓解。并以Cox比例风险模型分别行单因素及多因素回归,筛选预测和影响术后缓解的相关因素。结果:2009年2月至2014年12月在本中心接受经蝶生长激素腺瘤切除术的患者共63例,3例因资料不完整予以排除。其中男性21人,女性39人,发病男女比例1:1.86。入选者平均年龄47.9±11.2岁,平均病程5.8±5.9年。中位随访时间440.5天。缓解36例,不缓解24例,总缓解率60%。缓解组与未缓解组年龄、性别无统计学差异;微腺瘤与大腺瘤、侵袭性腺瘤与非侵袭性腺瘤、术前GH30μg/L组与术前GH≤30μg/L组、术中GH下降率40%组与术中GH下降率≤40%组缓解率均有统计学差异。K-M生存曲线及Cox回归分析结果提示腺瘤大小、腺瘤侵袭性、术前基础GH水平是影响缓解的重要因素。术中生长激素下降率、术后早期GH水平是预测术后缓解的重要指标。结论:术前高GH水平、大腺瘤、侵袭性腺瘤是垂体生长激素腺瘤术后缓解的不良因素。术中GH下降率40%对术后缓解具有一定的预测效果。术后第一日GH水平对于预测术后缓解具有良好的效果。
[Abstract]:Objective: to study the factors related to postoperative remission of pituitary growth hormone adenoma, and to explore the factors influencing and predicting postoperative remission of pituitary growth hormone adenoma. Methods: from February 2009 to December 2014, we retrospectively analyzed the patients undergoing transsphenoidal pituitary growth hormone adenectomy in our center. According to the condition of postoperative remission, we divided the two groups into two groups, and compared the difference of different factors between the two groups, and used the survival analysis method to draw the survival curve, and to judge whether the survival curve affected the postoperative remission. Univariate and multivariate regression were performed with Cox proportional risk model to screen the related factors to predict and influence postoperative remission. Results: from February 2009 to December 2014, 63 patients underwent transsphenoidal adenoma resection in our center. 3 patients were excluded because of incomplete data. Of these, 21 were male and 39 female, with a male to female ratio of 1: 1.86. The mean age was 47.9 卤11.2 years and the mean course of disease was 5.8 卤5.9 years. The median follow-up time was 440.5 days. There were 36 cases of remission and 24 cases of non-remission. The total remission rate was 60%. There was no significant difference in age and sex between remission group and non-remission group, microadenoma and macroadenoma, invasive adenoma and noninvasive adenoma, preoperative GH30 渭 g / L group and preoperative GH 鈮，
本文编号：2275972
[Abstract]:Objective: to study the factors related to postoperative remission of pituitary growth hormone adenoma, and to explore the factors influencing and predicting postoperative remission of pituitary growth hormone adenoma. Methods: from February 2009 to December 2014, we retrospectively analyzed the patients undergoing transsphenoidal pituitary growth hormone adenectomy in our center. According to the condition of postoperative remission, we divided the two groups into two groups, and compared the difference of different factors between the two groups, and used the survival analysis method to draw the survival curve, and to judge whether the survival curve affected the postoperative remission. Univariate and multivariate regression were performed with Cox proportional risk model to screen the related factors to predict and influence postoperative remission. Results: from February 2009 to December 2014, 63 patients underwent transsphenoidal adenoma resection in our center. 3 patients were excluded because of incomplete data. Of these, 21 were male and 39 female, with a male to female ratio of 1: 1.86. The mean age was 47.9 卤11.2 years and the mean course of disease was 5.8 卤5.9 years. The median follow-up time was 440.5 days. There were 36 cases of remission and 24 cases of non-remission. The total remission rate was 60%. There was no significant difference in age and sex between remission group and non-remission group, microadenoma and macroadenoma, invasive adenoma and noninvasive adenoma, preoperative GH30 渭 g / L group and preoperative GH 鈮，
本文编号：2275972
本文链接：https://www.wllwen.com/yixuelunwen/zlx/2275972.html
