消痞镇痛膏外敷联合奥施康定片治疗肺癌重度疼痛30例临床观察

发布时间：2018-10-21 19:30

【摘要】：目的观察消痞镇痛膏外敷联合奥施康定片治疗肺癌重度疼痛的临床疗效及安全性。方法 60例肺癌重度疼痛患者随机分为治疗组和对照组各30例。治疗组予消痞镇痛膏外敷联合奥施康定片口服;对照组予安慰剂外敷联合奥施康定片口服治疗,给药7天。观察两组患者治疗前后疼痛评分、奥施康定片日均消耗量、免疫功能指标及便秘伴随症状积分,并评价疼痛疗效。结果治疗组治疗后疼痛缓解率为90.0%,高于对照组的76.7%(P0.05);治疗组治疗后奥施康定片日均消耗量少于对照组(P0.05);两组患者治疗后免疫指标较治疗前均有所提高,且治疗组优于对照组(P0.01);两组患者治疗后卡氏评分较治疗前有所提高(P0.01),但治疗后两组卡氏评分比较差异无统计学意义(P0.05);治疗组的副反应发生率明显少于对照组(P0.05),且治疗组便秘伴随症状积分明显低于对照组(P0.01)。结论消痞镇痛膏与奥施康定片有协同、减毒、增效的作用,能有效的减轻癌痛,减少奥施康定片的日均消耗量及副反应,改善患者免疫功能,提高患者生活质量。
[Abstract]:Objective to observe the efficacy and safety of Xiaopi analgesia ointment combined with Oshkangding tablet in the treatment of severe pain of lung cancer. Methods 60 patients with severe lung cancer pain were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with Xiaopi analgesic ointment and Oshkangding tablet, while the control group was treated with placebo and Oshkangding tablets for 7 days. The pain score before and after treatment, the daily consumption of Oshkangding tablets, the immune function index and the constipation symptom score were observed, and the effect of pain was evaluated. Results the pain relief rate of the treatment group was 90.0%, which was higher than that of the control group (76.7%), the average daily consumption of the treatment group was less than that of the control group (P0.05). The treatment group was superior to the control group (P0.01), the two groups of patients after treatment increased the Karnoff score (P0.01), but after treatment there was no significant difference between the two groups (P0.05), the incidence of side effects in the treatment group was significantly lower than that in the control group (P0.05), and the incidence of side effects in the treatment group was significantly lower than that in the control group (P0.05). The score of constipation associated symptoms in the treatment group was significantly lower than that in the control group (P 0.01). Conclusion Xiaopi analgesic ointment and Oshkangding tablets have synergistic, attenuated and synergistic effects, which can effectively reduce cancer pain, reduce daily consumption and side effects of Oshkangding tablets, improve patients' immune function and improve patients' quality of life.
【作者单位】：湖南中医药大学;江苏省中西医结合医院;湖南省中医药研究院附属医院;
【基金】：国家自然科学基金(81373602)
【分类号】：R734.2

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