天冬氨酸转氨酶与中性粒细胞比值对肝癌患者TACE治疗预后的影响
发布时间：2018-10-23 14:28
【摘要】：目的探讨经导管肝动脉化疗栓塞(TACE)术前血清天冬氨酸转氨酶(AST)和中性粒细胞比值(ANRI)对肝细胞肝癌患者预后的评估价值。方法收集2008年1月至2011年6月期间107例肝细胞肝癌患者的临床资料,研究对象均成功施行TACE,以5年总生存率绘制ROC曲线确定截断值,对术前患者的ANRI、AST与淋巴细胞比值(ALRI)、AST与血小板计数比值(APRI)、中性粒细胞与淋巴细胞比值(NLR)、血小板计数与淋巴细胞比值(PLR)及其他临床病理参数进行单因素、多因素Logisitc回归分析及Kaplan-Meier生存分析,以确定上述因素对无病生存期(DFS)和生存期(OS)的预测价值。结果ANRI与HBs Ag、AST、肝硬化的存在、肿瘤大小、门静脉癌栓及肿瘤的复发具有相关性(P0.05)。通过单因素分析显示,ANRI、ALRI、APRI、NLR、PLR与接受TACE治疗肝癌患者的DFS和OS具有显著相关性(P0.05)。多因素Logisitc回归分析显示,ANRI被证明是该类患者DFS和OS的独立影响因素(P0.05)。Kaplan-Meier生存分析表明,术前ANRI7.8的患者行TACE治疗后预后较差。结论 TACE术前ANRI水平是肝细胞肝癌患者预后独立的预测因素,ANRI水平较高往往提示该类患者行TACE治疗的预后较差。
[Abstract]:Objective to evaluate the prognostic value of serum aspartate aminotransferase (AST) and neutrophil ratio (ANRI) in patients with hepatocellular carcinoma (HCC) before transcatheter hepatic artery chemoembolization (TACE). Methods the clinical data of 107 patients with hepatocellular carcinoma (HCC) from January 2008 to June 2011 were collected. TACE, was successfully performed to draw the ROC curve to determine the truncation value with 5-year overall survival rate. The ratio of ANRI,AST / lymphocyte to (ALRI), AST / platelet count ratio of (APRI), neutrophil to lymphocyte ratio (NLR), platelet count to lymphocyte ratio (PLR) and other clinicopathological parameters were studied. Multivariate Logisitc regression analysis and Kaplan-Meier survival analysis were used to determine the predictive value of these factors for disease-free survival (DFS) and survival (OS). Results ANRI was correlated with the presence of HBs Ag,AST, cirrhosis, tumor size, portal vein tumor thrombus and tumor recurrence (P0.05). Univariate analysis showed that ANRI,ALRI,APRI,NLR,PLR was significantly correlated with DFS and OS in patients with liver cancer treated with TACE (P0.05). Multivariate Logisitc regression analysis showed that ANRI was proved to be an independent factor of DFS and OS in this group of patients (P0.05). Kaplan-Meier survival analysis showed that the prognosis of patients with preoperative ANRI7.8 after TACE treatment was poor. Conclusion the level of ANRI before TACE is an independent predictor of the prognosis of HCC patients, and the high level of ANRI often indicates that the prognosis of the patients treated with TACE is poor.
【作者单位】： 贵州医科大学附属医院介入科;
【分类号】：R735.7
，
本文编号：2289520
[Abstract]:Objective to evaluate the prognostic value of serum aspartate aminotransferase (AST) and neutrophil ratio (ANRI) in patients with hepatocellular carcinoma (HCC) before transcatheter hepatic artery chemoembolization (TACE). Methods the clinical data of 107 patients with hepatocellular carcinoma (HCC) from January 2008 to June 2011 were collected. TACE, was successfully performed to draw the ROC curve to determine the truncation value with 5-year overall survival rate. The ratio of ANRI,AST / lymphocyte to (ALRI), AST / platelet count ratio of (APRI), neutrophil to lymphocyte ratio (NLR), platelet count to lymphocyte ratio (PLR) and other clinicopathological parameters were studied. Multivariate Logisitc regression analysis and Kaplan-Meier survival analysis were used to determine the predictive value of these factors for disease-free survival (DFS) and survival (OS). Results ANRI was correlated with the presence of HBs Ag,AST, cirrhosis, tumor size, portal vein tumor thrombus and tumor recurrence (P0.05). Univariate analysis showed that ANRI,ALRI,APRI,NLR,PLR was significantly correlated with DFS and OS in patients with liver cancer treated with TACE (P0.05). Multivariate Logisitc regression analysis showed that ANRI was proved to be an independent factor of DFS and OS in this group of patients (P0.05). Kaplan-Meier survival analysis showed that the prognosis of patients with preoperative ANRI7.8 after TACE treatment was poor. Conclusion the level of ANRI before TACE is an independent predictor of the prognosis of HCC patients, and the high level of ANRI often indicates that the prognosis of the patients treated with TACE is poor.
【作者单位】： 贵州医科大学附属医院介入科;
【分类号】：R735.7
，
本文编号：2289520
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