中性粒细胞与淋巴细胞比值对胰腺癌预后的影响
发布时间：2018-11-08 11:16
【摘要】：目的探讨中性粒细胞计数与淋巴细胞计数比值(neutrophil to lymphocyte ratio,NLR)对胰腺癌患者预后的影响。方法回顾性分析2010年1月~2013年1月105例接受根治性手术的胰腺癌患者病历资料。通过Log-rank单因素分析包括NLR在内的临床病理特征对术后1年生存率及中位生存时间的影响。并通过Cox风险模型将有意义的变量进行多因素分析。结果依据患者术前血常规检查,计算NLR,依据四分位点,分为NLR2.1、2.1≤NLR2.8、2.8≤NLR4.3、NLR≥4.3 4个组,各组患者的术后中位生存时间分别为25、16、11、5个月。NLR2.1、2.1≤NLR2.8、2.8≤NLR4.3 3组1年生存率分别为84.7%、79.8%、36.2%,其中NLR≥4.3组患者1年生存率低于5%,差异有统计学意义(P均0.05)。多因素分析显示,术前外周血NLR、肿瘤直径、肿瘤分化程度、淋巴结转移、脉管侵犯、肿瘤T分期、远处转移是影响胰腺癌患者预后的独立危险因素(P均0.05)。结论术前外周血NLR可作为评价胰腺癌患者根治性手术后预后的指标。
[Abstract]:Objective to investigate the effect of the ratio of neutrophil count and lymphocyte count (neutrophil to lymphocyte ratio,NLR) on the prognosis of pancreatic cancer patients. Methods the medical records of 105 patients with pancreatic cancer undergoing radical surgery from January 2010 to January 2013 were retrospectively analyzed. The effect of clinicopathological features, including NLR, on 1 year survival rate and median survival time was analyzed by Log-rank univariate analysis. And the Cox risk model will be meaningful variables for multivariate analysis. Results according to the preoperative blood routine examination, the NLR, was calculated and divided into 4 groups: NLR2.1,2.1 鈮，
本文编号：2318323
[Abstract]:Objective to investigate the effect of the ratio of neutrophil count and lymphocyte count (neutrophil to lymphocyte ratio,NLR) on the prognosis of pancreatic cancer patients. Methods the medical records of 105 patients with pancreatic cancer undergoing radical surgery from January 2010 to January 2013 were retrospectively analyzed. The effect of clinicopathological features, including NLR, on 1 year survival rate and median survival time was analyzed by Log-rank univariate analysis. And the Cox risk model will be meaningful variables for multivariate analysis. Results according to the preoperative blood routine examination, the NLR, was calculated and divided into 4 groups: NLR2.1,2.1 鈮，
本文编号：2318323
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