前列腺癌骨转移的特点及其相关危险因素分析

发布时间：2018-11-14 07:25

【摘要】：目的探讨前列腺癌骨转移的临床特点及其危险因素。方法回顾性分析2006年6月-2016年6月南昌大学第一附属医院收治的、经穿刺活检或术后病理检查确诊为前列腺癌患者的临床资料,记录首次入院时的一般资料、化验检查结果及病理切片Gleason评分,分析各临床因素与骨转移发生的关系,明确骨转移发生的相关危险因素。结果共纳入585例前列腺癌患者,其中发生骨转移228例,无骨转移357例。在骨转移患者中,骨盆转移发生率最高,占81.58%,其次是脊柱转移(63.16%)和肋骨转移(58.33%),锁骨转移最少(14.47%)。Logistic回归分析显示年龄71.5岁、碱性磷酸酶(ALP)85.5U/L、前列腺特异性抗原(PSA)79.88μg/L和Gleason评分7.5分是前列腺癌骨转移的危险因素。ROC曲线分析显示,上述各因素诊断骨转移的灵敏度分别为56.1%、66.7%、68.4%、56.1%,特异度分别为56.6%、81.8%、70.0%、65.3%。结论前列腺癌骨转移以骨盆转移最为多见,年龄、ALP、PSA及Gleason评分是前列腺癌发生骨转移的危险因素。
[Abstract]:Objective to investigate the clinical features and risk factors of bone metastasis in prostate cancer. Methods the clinical data of patients with prostate cancer diagnosed by puncture biopsy or postoperative pathological examination in the first affiliated Hospital of Nanchang University from June 2006 to June 2016 were analyzed retrospectively, and the general data of the first admission were recorded. The relationship between clinical factors and bone metastasis was analyzed, and the related risk factors of bone metastasis were identified. Results there were 585 cases of prostate cancer including 228 cases of bone metastasis and 357 cases of no bone metastasis. The incidence of pelvic metastasis was the highest (81.58%), followed by spinal metastasis (63.16%) and rib metastasis (58.33%), and clavicle metastasis was the least (14.47%) by). Logistic regression analysis. Alkaline phosphatase (ALP) 85.5 U / L, prostate specific antigen (PSA) 79.88 渭 g / L and Gleason score 7.5 were risk factors for bone metastasis of prostate cancer. The sensitivity of the above factors in the diagnosis of bone metastasis was 56.1 and 68.7, and the specificity was 56.6 and 81.8, respectively. Conclusion pelvic metastasis is the most common bone metastasis in prostate cancer. Age, ALP,PSA and Gleason scores are the risk factors for bone metastasis of prostate cancer.
【作者单位】：南昌大学第一附属医院骨科;
【基金】：江西省主要学科带头人资助计划(20162BCB22022) 江西省杰出青年人才资助计划(20162BCB23057)~~
【分类号】：R737.25

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