山茱萸提取物对大鼠原发性肝癌组织中B7-H6表达的影响
[Abstract]:Objective: to investigate the effect of Fructus Corni extract on the expression of B7-H6 in primary hepatic carcinoma (hepatocellular carcinoma,HCC) rats. Methods: sixty SD rats were randomly divided into three groups: model group, matrine group and Cornus officinalis group. The rats were induced by diethylnitrosamine. Rats in the model group were given 0.9%Na Cl solution. The number of tumor nodules on the liver surface and tumor inhibition rate were counted, and the pathological changes of liver cancer tissues were observed by HE staining. Immunohistochemical method and Western blot method were used to detect the expression of B7-H6 in model group, matrine group and Cornus officinalis group. Results: the number of hepatoma nodules in Matrine group and Cornus officinalis group was significantly lower than that in model group (P0.05), and the inhibitory rate in Fructus Corni group was significantly higher than that in matrine group (P0.05). Immunohistochemical results showed that the positive expression of B7-H6 in the liver cancer tissues of Cornus officinalis group and matrine group was significantly higher than that in the model group (P0.05). The positive expression of B7-H6 in Cornus officinalis group was significantly higher than that in matrine group (P0.05). Western blot method). The expression of B7-H6 protein in Cornus officinalis group and matrine group was significantly higher than that in model group (P0.05). The protein expression of B7-H6 in Cornus officinalis group was significantly higher than that in matrine group (P0.05). Conclusion: the extract of Fructus Corni may inhibit the growth of rat liver cancer by upregulating the expression of B7-H6 in tumor tissue.
【作者单位】： 郑州人民医院肿瘤内科;
【分类号】：R735.7
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